Targeted Precision Cryotherapy for Acne Vulgaris

Overview

Journal Skin Res Technol

Specialty Biomedical Engineering

Date 2024 Sep 2

PMID 39221850

Authors

Ji Yeon Hong

Ka Ram Kim

Hyun Jung Kim

Joon Seok

Kui Young Park

Affiliations

Soon will be listed here.

Abstract

Background: Acne vulgaris poses a significant dermatological challenge, necessitating alternative treatments due to limitations and side effects associated with current therapies. This pilot clinical trial investigated the feasibility and efficacy of precision cryotherapy for acne vulgaris.

Methods: A total of 20 volunteers underwent targeted precision cryotherapy using a carbon dioxide-based device. Treatment outcomes were assessed using various parameters, including Investigator Global Assessment (IGA) score, acne lesion count, erythema index (EI), global evaluation score, and participant satisfaction. Safety monitoring included adverse event reporting and physical examination.

Results: Precision cryotherapy demonstrated a significant reduction (90.25%) in the acne lesion count by week 4, with clinical improvement indicated by IGA score reduction (p < 0.001). The EI showed notable improvements at weeks 1, 2, and 4. The global evaluation score demonstrated a 75%-100% clinical improvement at Visit 4. Participants reported high satisfaction (6.75 ± 0.79) with the procedure. No adverse event or discomfort was reported.

Conclusion: Precision cryotherapy effectively improved acne lesions, which was safe and satisfactory for participants. These findings suggest its potential as an alternative therapeutic modality, especially for populations with limited treatment options. Further research is needed to validate the results and explore underlying mechanisms.

References

Tzellos T, Zampeli V, Makrantonaki E, Zouboulis C . Treating acne with antibiotic-resistant bacterial colonization. Expert Opin Pharmacother. 2011; 12(8):1233-47. DOI: 10.1517/14656566.2011.553192. View

Prevost N, English J . Isotretinoin: update on controversial issues. J Pediatr Adolesc Gynecol. 2013; 26(5):290-3. DOI: 10.1016/j.jpag.2013.05.007. View

Park K, Han H, Hong J, Seo S, Lee S . Gold nanoshell-mediated photothermal therapy for acne vulgaris. Dermatol Ther. 2019; 33(1):e13189. DOI: 10.1111/dth.13189. View

Dzubow L . Histologic and temperature alterations induced by skin refrigerants. J Am Acad Dermatol. 1985; 12(5 Pt 1):796-810. DOI: 10.1016/s0190-9622(85)70099-0. View

Knutsen-Larson S, Dawson A, Dunnick C, Dellavalle R . Acne vulgaris: pathogenesis, treatment, and needs assessment. Dermatol Clin. 2011; 30(1):99-106, viii-ix. DOI: 10.1016/j.det.2011.09.001. View

Nouri K, Chartier T, Eaglstein W, Taylor J . Cryotherapy for psoriasis. Arch Dermatol. 1998; 133(12):1608-9. View

Gage A, Meenaghan M, Natiella J, GREENE Jr G . Sensitivity of pigmented mucosa and skin to freezing injury. Cryobiology. 1979; 16(4):348-61. DOI: 10.1016/0011-2240(79)90048-8. View

Lee E, Lee H, Park K, Lee W . Effect of a new cryotherapy device on an itchy sensation in patients with mild atopic dermatitis. J Cosmet Dermatol. 2021; 20(9):2906-2910. DOI: 10.1111/jocd.13975. View

Zdrada-Nowak J, Stolecka-Warzecha A, Odrzywolek W, Deda A, Blonska-Fajfrowska B, Wilczynski S . Hyperspectral assessment of acne skin exposed to intense pulsed light (IPL) intense pulsed light in acne treatment. Skin Res Technol. 2023; 29(6):e13338. PMC: 10209844. DOI: 10.1111/srt.13338. View

10.

Jalian H, Tam J, Vuong L, Fisher J, Garibyan L, Mihm M . Selective Cryolysis of Sebaceous Glands. J Invest Dermatol. 2015; 135(9):2173-2180. DOI: 10.1038/jid.2015.148. View

11.

Shamsadini S, Varesvazirian M, Shamsadini A . Cryotherapy as a treatment for psoriasis. Dermatol Online J. 2005; 11(2):21. View

12.

Guo Y, Zeng M, Yuan Y, Yuan M, Chen Y, Yu H . Photodynamic therapy treats acne by altering the composition of the skin microbiota. Skin Res Technol. 2023; 29(1):e13269. PMC: 9838775. DOI: 10.1111/srt.13269. View

13.

Park S, Shin S, Koh Y, Kim G, Rho N, Park K . Cold anesthesia for pain reduction during intralesional steroid injection for nodulocystic acne. J Cosmet Dermatol. 2023; 22(12):3375-3378. DOI: 10.1111/jocd.15829. View

14.

Ma J, Yu X, Lv J, Lin D, Lin J, Bai Y . Cryotherapy mediates histopathological and microstructural changes during the treatment of skin and subcutaneous tumors in dogs. Cryobiology. 2020; 98:164-171. DOI: 10.1016/j.cryobiol.2020.11.006. View

15.

Zhang X, Zhang Z, Tao H, He X, Hsu K, Wang W . Comprehensive assessment of the efficacy and safety of a clay mask in oily and acne skin. Skin Res Technol. 2023; 29(11):e13513. PMC: 10626287. DOI: 10.1111/srt.13513. View

16.

Rho N . Revisiting the Role of Local Cryotherapy for Acne Treatment: A Review and Update. J Clin Med. 2023; 12(1). PMC: 9821281. DOI: 10.3390/jcm12010026. View

17.

Kaminsky A . Less common methods to treat acne. Dermatology. 2003; 206(1):68-73. DOI: 10.1159/000067824. View

18.

Knaggs H, Holland D, Morris C, Wood E, Cunliffe W . Quantification of cellular proliferation in acne using the monoclonal antibody Ki-67. J Invest Dermatol. 1994; 102(1):89-92. DOI: 10.1111/1523-1747.ep12371738. View

19.

Kwack M, Song C, Lee S, Ha G, Kim G, Lee W . Effect of a Temperature-Adjustable Cryotherapy Device on Mice with Lysophosphatidic Acid-Induced Pruritus. Ann Dermatol. 2023; 35(5):381-385. PMC: 10579573. DOI: 10.5021/ad.21.195. View

20.

Lee Y, Kim S, Kim J, Kim J, Song S, Lee W . Tissue-remodelling M2 Macrophages Recruits Matrix Metallo-proteinase-9 for Cryotherapy-induced Fibrotic Resolution during Keloid Treatment. Acta Derm Venereol. 2020; 100(17):adv00306. PMC: 9274924. DOI: 10.2340/00015555-3665. View