Applications of Pyroptosis Activators in Tumor Immunotherapy

Overview

Journal Mater Today Bio

Specialty Biomedical Engineering

Date 2024 Sep 2

PMID 39221221

Authors

Xin Bao

Mengmeng Sun

Lingfei Meng

Hong Zhang

Xuan Yi

Peng Zhang

Affiliations

Soon will be listed here.

Abstract

Contemporary progress in tumor immunotherapy has solidified its role as an effective approach in combating cancer. Nonetheless, the prevalent "immune cold" state within the tumor microenvironment poses a substantial barrier to its efficacy. Addressing this, pyroptosis-a gasdermin-mediated programmed cell death characterized by its inflammatory profile-emerges as a crucial mechanism. It catalyzes the release of vast quantities of pro-inflammatory cytokines and immunogens, potentially transforming immunosuppressive "cold" tumors into reactive "hot" ones. Herein, we will initially present an overview of pyroptosis as a distinct form of cell death, along with its molecular mechanisms. Subsequently, we will focus on introducing how pyroptosis activators are utilized in the field of tumor immunotherapy. Insights gained from applications of pyroptosis activators in tumor immunotherapy could lead to the development of safe and efficient pyroptosis activators, significantly enriching the arsenal for tumor immunotherapy.

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