Association of Serum Vitamin D with Diagnosis and Growth of Abdominal Aortic Aneurysm

Overview

Journal JVS Vasc Sci

Specialty Cardiology & Vascular Diseases

Date 2024 Sep 2

PMID 39219591

Authors

Shivshankar Thanigaimani

Rachel E Neale

Mary Waterhouse

Joseph V Moxon

Bu B Yeap

Paul E Norman

Leon Flicker

Graeme J Hankey

Jason Jenkins

Frank Quigley

Michael W Clarke

Jonathan Golledge

Affiliations

Soon will be listed here.

Abstract

Objective: We examined the associations between 25-hydroxy vitamin D (25(OH)D) concentration and the diagnosis and growth of abdominal aortic aneurysm (AAA).

Methods: AAA cases and healthy controls were recruited from vascular centers or the community. A subset of participants with AAA were monitored by repeat ultrasound examination to assess AAA growth. Serum 25(OH)D concentration was measured using a validated mass spectrometry method and categorized into guideline-recommended cut-points after deseasonalization. The associations between deseasonalized 25(OH)D concentration and AAA diagnosis and growth were examined using logistic regression and linear mixed effects modeling.

Results: A total of 4673 participants consisting of 873 (455 controls and 418 cases) from Queensland and 3800 (3588 controls and 212 cases) from Western Australia were recruited. For every 1 standard deviation increase in 25(OH)D concentration, odds of AAA diagnosis was significantly reduced in both Queensland (adjusted odds ratio: 0.81; 95% confidence interval [CI]: 0.69-0.95; = .009) and Western Australia (adjusted odds ratio: 0.80; 95% CI: 0.68-0.94; = .005) cohorts. A subset of 310 eligible participants with small AAA from both regions were followed for a median of 4.2 (interquartile range: 2.0-5.8) years. Compared with vitamin D sufficient participants (50 to ˂75 nmol/L), annual mean AAA growth was significantly greater in those with higher vitamin D (≥75 nmol/L) (adjusted mean difference: 0.1 mm/y, 95% CI: 0.1-0.2; < .001).

Conclusions: High 25(OH)D concentration was paradoxically associated with a lower likelihood of AAA diagnosis and faster AAA growth. Further research is needed to resolve these conflicting findings.

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