» Articles » PMID: 39218892

The Correlation Between the Thyroid Function and Urinary Iodine/creatinine Ratio of Pregnant Women Attending a Tertiary Hospital in Beijing, China, During Different Trimesters

Overview
Publisher Biomed Central
Specialty Endocrinology
Date 2024 Sep 1
PMID 39218892
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: This study investigated the correlation between thyroid function and urinary iodine/creatinine ratio (UI/Cr) in pregnant women during different trimesters and explored potential influencing factors.

Methods: In this cross-sectional study, serum levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and UI/Cr were measured in 450 pregnant women. Correlations were analyzed using Pearson's correlation coefficient and multiple linear regression. Subgroup analyses were performed based on age, body mass index (BMI), parity, gestational age, education, occupation, and family history of thyroid disorders.

Results: UI/Cr was positively correlated with FT4 levels in the first and second trimesters, particularly in women with older age, higher BMI, multiparity, higher education, and employment. No significant correlations were found between UI/Cr and TSH or FT3 levels.

Conclusion: UI/Cr is positively correlated with FT4 levels in early pregnancy, especially in women with certain risk factors. Regular monitoring of iodine status and thyroid function is recommended for pregnant women to ensure optimal maternal and fetal health.

References
1.
Baloch Z, Carayon P, Conte-Devolx B, Demers L, Feldt-Rasmussen U, Henry J . Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid. 2003; 13(1):3-126. DOI: 10.1089/105072503321086962. View

2.
Korevaar T, Muetzel R, Medici M, Chaker L, Jaddoe V, de Rijke Y . Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study. Lancet Diabetes Endocrinol. 2015; 4(1):35-43. DOI: 10.1016/S2213-8587(15)00327-7. View

3.
Farebrother J, Zimmermann M, Andersson M . Excess iodine intake: sources, assessment, and effects on thyroid function. Ann N Y Acad Sci. 2019; 1446(1):44-65. DOI: 10.1111/nyas.14041. View

4.
Fitzpatrick D, Russell M . Diagnosis and management of thyroid disease in pregnancy. Obstet Gynecol Clin North Am. 2010; 37(2):173-93. DOI: 10.1016/j.ogc.2010.02.007. View

5.
Glinoer D . The regulation of thyroid function during normal pregnancy: importance of the iodine nutrition status. Best Pract Res Clin Endocrinol Metab. 2004; 18(2):133-52. DOI: 10.1016/j.beem.2004.03.001. View