Clinical Application of Phage Immunoprecipitation Sequencing to Diagnose Enterovirus D68 As the Underlying Etiology in a Case of Guillain-Barré Syndrome

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2024 Aug 31

PMID 39215587

Authors

Fang Fang Li

Alison Faber

Jessica M Caleta

David M Goldfarb

Inna Sekirov

Natalie A Prystajecky

Jocelyn A Srigley

Ram Mishaal

Agatha N Jassem

Affiliations

Soon will be listed here.

Abstract

Guillain-Barré syndrome (GBS) is an acute peripheral neuropathy often preceded by respiratory or gastrointestinal infections, though molecular testing of cerebrospinal fluid is often inconclusive. In a recent case of severe pediatric GBS in British Columbia, Canada, we detected cerebrospinal fluid antibodies against enterovirus D to link GBS with prior enterovirus D68 respiratory infection.

References

Ramachandran P, Wilson M . Diagnostic Testing of Neurologic Infections. Neurol Clin. 2018; 36(4):687-703. PMC: 6789377. DOI: 10.1016/j.ncl.2018.07.004. View

Yuki N, Hartung H . Guillain-Barré syndrome. N Engl J Med. 2012; 366(24):2294-304. DOI: 10.1056/NEJMra1114525. View

Mohan D, Wansley D, Sie B, Noon M, Baer A, Laserson U . PhIP-Seq characterization of serum antibodies using oligonucleotide-encoded peptidomes. Nat Protoc. 2018; 13(9):1958-1978. PMC: 6568263. DOI: 10.1038/s41596-018-0025-6. View

Jacobs B, Rothbarth P, van der Meche F, Herbrink P, Schmitz P, de Klerk M . The spectrum of antecedent infections in Guillain-Barré syndrome: a case-control study. Neurology. 1998; 51(4):1110-5. DOI: 10.1212/wnl.51.4.1110. View

Kuwabara S . Guillain-barré syndrome. Curr Neurol Neurosci Rep. 2007; 7(1):57-62. DOI: 10.1007/s11910-007-0022-6. View

Johnson T, Larman H, Lee M, Whitehead S, Kowalak J, Toro C . Chronic Dengue Virus Panencephalitis in a Patient with Progressive Dementia with Extrapyramidal Features. Ann Neurol. 2019; 86(5):695-703. PMC: 11502142. DOI: 10.1002/ana.25588. View

Hasan I, Saif-Ur-Rahman K, Hayat S, Papri N, Jahan I, Azam R . Guillain-Barré syndrome associated with SARS-CoV-2 infection: A systematic review and individual participant data meta-analysis. J Peripher Nerv Syst. 2020; 25(4):335-343. DOI: 10.1111/jns.12419. View

Gu Z, Eils R, Schlesner M . Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics. 2016; 32(18):2847-9. DOI: 10.1093/bioinformatics/btw313. View

Schubert R, Hawes I, Ramachandran P, Ramesh A, Crawford E, Pak J . Pan-viral serology implicates enteroviruses in acute flaccid myelitis. Nat Med. 2019; 25(11):1748-1752. PMC: 6858576. DOI: 10.1038/s41591-019-0613-1. View

10.

Mina M, Kula T, Leng Y, Li M, de Vries R, Knip M . Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science. 2019; 366(6465):599-606. PMC: 8590458. DOI: 10.1126/science.aay6485. View

11.

Willison H, Jacobs B, van Doorn P . Guillain-Barré syndrome. Lancet. 2016; 388(10045):717-27. DOI: 10.1016/S0140-6736(16)00339-1. View

12.

Williams C, Thomas R, Pickersgill T, Lyons M, Lowe G, Stiff R . Cluster of atypical adult Guillain-Barré syndrome temporally associated with neurological illness due to EV-D68 in children, South Wales, United Kingdom, October 2015 to January 2016. Euro Surveill. 2016; 21(4). DOI: 10.2807/1560-7917.ES.2016.21.4.30119. View

13.

Xu G, Kula T, Xu Q, Li M, Vernon S, Ndungu T . Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science. 2015; 348(6239):aaa0698. PMC: 4844011. DOI: 10.1126/science.aaa0698. View

14.

Skowronski D, Chambers C, Sabaiduc S, Murti M, Gustafson R, Pollock S . Systematic community- and hospital-based surveillance for enterovirus-D68 in three Canadian provinces, August to December 2014. Euro Surveill. 2016; 20(43). DOI: 10.2807/1560-7917.ES.2015.20.43.30047. View

15.

Mishra N, Ng T, Marine R, Jain K, Ng J, Thakkar R . Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis. mBio. 2019; 10(4). PMC: 6692520. DOI: 10.1128/mBio.01903-19. View