Article: Immunocytochemical evidence for the ability of the human pharyngeal hypophysis to respond to change in endocrine feedback

Two pharyngeal hypophyses from patients with endocrine disorder were examined light microscopically and immunocytochemically. The pharyngeal hypophysis from a patient with primary hypothyroidism was hypertrophic, with TSH cell hyperplasia; while that from a patient treated with metoclopramide, a dopamine-receptor-blocking drug, showed PRL cell hyperplasia. These findings strongly suggest that under certain circumstances the pharyngeal hypophysis is able to respond with specific changes to variations in the endocrine feedback.

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References

1.

VAN BUREN J, BERGENSTAL D . An evaluation of graded hypophysectomy in man: a quantitative functional and anatomical study. Cancer. 1960; 13:155-71. DOI: 10.1002/1097-0142(196001/02)13:1<155::aid-cncr2820130127>3.0.co;2-0. View

2.

McPhie J, BECK J . The histological features and human growth hormone content of the pharyngeal pituitary gland in normal and endocrinologically-disturbed patients. Clin Endocrinol (Oxf). 1973; 2(2):157-73. DOI: 10.1111/j.1365-2265.1973.tb00416.x. View

3.

McGrath P . Aspects of the human pharyngeal hypophysis in normal and anencephalic fetuses and neonates and their possible significance in the mechanism of its control. J Anat. 1978; 127(Pt 1):65-81. PMC: 1235644. View

4.

McGrath P . The trans-sphenoidal vascular route in relation to the human pharyngeal hypophysis. J Anat. 1972; 113(Pt 3):383-90. PMC: 1271410. View

5.

McPhie J, BECK J . Growth hormone in the normal human pharyngeal pituitary gland. Nature. 1968; 219(5154):625-6. DOI: 10.1038/219625a0. View

6.

Hachmeister U . [Position of the pharyngeal hypophysis in the hypothalamus-adenohypophysis system]. Endokrinologie. 1967; 51(3):145-63. View

7.

McGrath P . The extra-sellar post-hypophysectomy remnant. Br J Surg. 1969; 56(1):64-7. DOI: 10.1002/bjs.1800560112. View

8.

Ciocca D, Puy L, Stati A . Identification of seven hormone-producing cell types in the human pharyngeal hypophysis. J Clin Endocrinol Metab. 1985; 60(1):212-6. DOI: 10.1210/jcem-60-1-212. View

9.

Melchionna R, Moore R . The pharyngeal pituitary gland. Am J Pathol. 2009; 14(6):763-772.1. PMC: 1964963. View

10.

Childs G, Unabia G . Application of the avidin-biotin-peroxidase complex (ABC) method to the light microscopic localization of pituitary hormones. J Histochem Cytochem. 1982; 30(7):713-6. DOI: 10.1177/30.7.6286753. View

11.

Asa S, Penz G, Kovacs K, EZRIN C . Prolactin cells in the human pituitary. A quantitative immunocytochemical analysis. Arch Pathol Lab Med. 1982; 106(7):360-3. View

12.

Aono T, SHIOJI T, Kinugasa T, Onishi T, Kurachi K . Clinical and endocrinological analyses of patients with galactorrhea and menstrual disorders due to sulpiride or metoclopramide. J Clin Endocrinol Metab. 1978; 47(3):675-80. DOI: 10.1210/jcem-47-3-675. View

Immunocytochemical Evidence for the Ability of the Human Pharyngeal Hypophysis to Respond to Change in Endocrine Feedback