From Field to Pharmacy: Isolation, Characterization and Tableting Behaviour of Microcrystalline Cellulose from Wheat and Corn Harvest Residues

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2024 Aug 29

PMID 39204435

Authors

Djordje Medarevic

Masa cezek

Aleksandar Knezevic

Erna Turkovic

Tanja Barudzija

Stevan Samardzic

Zoran Maksimovic

Affiliations

Soon will be listed here.

Abstract

A lack of strategies for the utilization of harvest residues (HRs) has led to serious environmental problems due to an accumulation of these residues or their burning in the field. In this study, wheat and corn HRs were used as feedstock for the production of microcrystalline cellulose (MCC) by treatment with 2-8% sodium hydroxide, 10% hydrogen peroxide and further hydrolysis with 1-2 M hydrochloric acid. The changes in the FT-IR spectra and PXRD diffractograms after chemical treatment confirmed the removal of most of the lignin, hemicellulose and amorphous fraction of cellulose. A higher degree of crystallinity was observed for MCC obtained from corn HRs, which was attributed to a more efficient removal of lignin and hemicellulose by a higher sodium hydroxide concentration, which facilitates the dissolution of amorphous cellulose during acid hydrolysis. MCC obtained from HRs exhibited lower bulk density and poorer flow properties but similar or better tableting properties compared to commercial MCC (Ceolus PH101). The lower ejection and detachment stress suggests that MCC isolated from HRs requires less lubricant compared to commercial MCC. This study showed that MCC isolated from wheat and corn HRs exhibits comparable tableting behaviour like commercial sample, further supporting this type of agricultural waste utilization.

Citing Articles

Antioxidant, Enzyme-Inhibitory and Antimicrobial Activity of Underutilized Wheat and Maize Crop Residues.

Samardzic S, Velickovic I, Milenkovic M, Arsenijevic J, Medarevic D, Maksimovic Z Plants (Basel). 2025; 14(3).

PMID: 39942908 PMC: 11820700. DOI: 10.3390/plants14030346.

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