Therapeutic Potential of Various Intermittent Fasting Regimens in Alleviating Type 2 Diabetes Mellitus and Prediabetes: A Narrative Review

Overview

Journal Nutrients

Date 2024 Aug 29

PMID 39203828

Authors

Sthembiso Msane

Andile Khathi

Aubrey Sosibo

Affiliations

Soon will be listed here.

Abstract

Intermittent fasting has drawn significant interest in the clinical research community due to its potential to address metabolic complications such as obesity and type 2 diabetes mellitus. Various intermittent fasting regimens include alternate-day fasting (24 h of fasting followed by 24 h of eating), time-restricted fasting (fasting for 14 h and eating within a 10 h window), and the 5:2 diet (fasting for two days and eating normally for the other five days). Intermittent fasting is associated with a reduced risk of type 2 diabetes mellitus-related complications and can slow their progression. The increasing global prevalence of type 2 diabetes mellitus highlights the importance of early management. Since prediabetes is a precursor to type 2 diabetes mellitus, understanding its progression is essential. However, the long-term effects of intermittent fasting on prediabetes are not yet well understood. Therefore, this review aims to comprehensively compile existing knowledge on the therapeutic effects of intermittent fasting in managing type 2 diabetes mellitus and prediabetes.

Citing Articles

The Effect of the 14:10-Hour Time-Restricted Feeding (TRF) Regimen on Selected Markers of Glucose Homeostasis in Diet-Induced Prediabetic Male Sprague Dawley Rats.

Msane S, Khathi A, Sosibo A Nutrients. 2025; 17(2).

PMID: 39861423 PMC: 11768421. DOI: 10.3390/nu17020292.

The 5:2 Diet Affects Markers of Insulin Secretion and Sensitivity in Subjects with and without Type 2 Diabetes-A Non-Randomized Controlled Trial.

Ekberg N, Hellberg A, Sundqvist M, Linden Hirschberg A, Catrina S, Brismar K Int J Mol Sci. 2024; 25(17).

PMID: 39273678 PMC: 11395907. DOI: 10.3390/ijms25179731.

References

Durstine J . Effect of aerobic exercise on high-density lipoprotein cholesterol: a meta-analysis. Clin J Sport Med. 2008; 18(1):107-8. DOI: 10.1097/01.jsm.0000307723.53749.00. View

Medagama A, Galgomuwa M . Lack of infrastructure, social and cultural factors limit physical activity among patients with type 2 diabetes in rural Sri Lanka, a qualitative study. PLoS One. 2018; 13(2):e0192679. PMC: 5819806. DOI: 10.1371/journal.pone.0192679. View

Martens C, Rossman M, Mazzo M, Jankowski L, Nagy E, Denman B . Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults. Geroscience. 2020; 42(2):667-686. PMC: 7206473. DOI: 10.1007/s11357-020-00156-6. View

Cui Y, Cai T, Zhou Z, Mu Y, Lu Y, Gao Z . Health Effects of Alternate-Day Fasting in Adults: A Systematic Review and Meta-Analysis. Front Nutr. 2020; 7:586036. PMC: 7732631. DOI: 10.3389/fnut.2020.586036. View

Reasner C, Olansky L, Seck T, Williams-Herman D, Chen M, Terranella L . The effect of initial therapy with the fixed-dose combination of sitagliptin and metformin compared with metformin monotherapy in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2011; 13(7):644-52. DOI: 10.1111/j.1463-1326.2011.01390.x. View

Guemes M, Rahman S, Hussain K . What is a normal blood glucose?. Arch Dis Child. 2015; 101(6):569-574. DOI: 10.1136/archdischild-2015-308336. View

Ortega R . Importance of functional foods in the Mediterranean diet. Public Health Nutr. 2007; 9(8A):1136-40. DOI: 10.1017/S1368980007668530. View

Olefsky J, Farquhar J, Reaven G . Reappraisal of the role of insulin in hypertriglyceridemia. Am J Med. 1974; 57(4):551-60. DOI: 10.1016/0002-9343(74)90006-0. View

Corley B, Carroll R, Hall R, Weatherall M, Parry-Strong A, Krebs J . Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial. Diabet Med. 2018; 35(5):588-594. DOI: 10.1111/dme.13595. View

10.

Kossoff E, McGrogan J . Worldwide use of the ketogenic diet. Epilepsia. 2005; 46(2):280-9. DOI: 10.1111/j.0013-9580.2005.42704.x. View

11.

Lean M . Banting Memorial Lecture 2021-Banting, banting, banter and bravado: Convictions meet evidence in the scientific process: Diabetes UK Professional Conference, 27 April 2021. Diabet Med. 2021; 38(11):e14643. DOI: 10.1111/dme.14643. View

12.

Nowosad K, Sujka M . Effect of Various Types of Intermittent Fasting (IF) on Weight Loss and Improvement of Diabetic Parameters in Human. Curr Nutr Rep. 2021; 10(2):146-154. PMC: 8102292. DOI: 10.1007/s13668-021-00353-5. View

13.

Rattarasarn C . Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes. Adipocyte. 2018; 7(2):71-80. PMC: 6152525. DOI: 10.1080/21623945.2018.1429784. View

14.

McDonald R, Ramsey J . Honoring Clive McCay and 75 years of calorie restriction research. J Nutr. 2010; 140(7):1205-10. PMC: 2884327. DOI: 10.3945/jn.110.122804. View

15.

Catenacci V, Pan Z, Ostendorf D, Brannon S, Gozansky W, Mattson M . A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (Silver Spring). 2016; 24(9):1874-83. PMC: 5042570. DOI: 10.1002/oby.21581. View

16.

Yun N, Nah J, Lee M, Wu D, Pae M . Post-Effects of Time-Restricted Feeding against Adipose Tissue Inflammation and Insulin Resistance in Obese Mice. Nutrients. 2023; 15(11). PMC: 10255447. DOI: 10.3390/nu15112617. View

17.

Arciero P, Poe M, Mohr A, Ives S, Arciero A, Sweazea K . Intermittent fasting and protein pacing are superior to caloric restriction for weight and visceral fat loss. Obesity (Silver Spring). 2022; 31 Suppl 1:139-149. PMC: 10107279. DOI: 10.1002/oby.23660. View

18.

He L . Metformin and Systemic Metabolism. Trends Pharmacol Sci. 2020; 41(11):868-881. PMC: 7572679. DOI: 10.1016/j.tips.2020.09.001. View

19.

Davies M, Khunti K . Insulin management in overweight or obese type 2 diabetes patients: the role of insulin glargine. Diabetes Obes Metab. 2008; 10 Suppl 2:42-9. DOI: 10.1111/j.1463-1326.2008.00844.x. View

20.

Das S, Gilhooly C, Golden J, Pittas A, Fuss P, Cheatham R . Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial. Am J Clin Nutr. 2007; 85(4):1023-30. DOI: 10.1093/ajcn/85.4.1023. View