The Anti-Constipation Effect of Bifidobacterium Longum W11 Is Likely Due to a Key Genetic Factor Governing Arabinan Utilization

Overview

Journal Microorganisms

Specialty Microbiology

Date 2024 Aug 29

PMID 39203468

Authors

Francesco DI Pierro

Nicola Zerbinati

Massimiliano Cazzaniga

Alexander Bertuccioli

Chiara Maria Palazzi

Ilaria Cavecchia

Mariarosaria Matera

Edoardo Labrini

Valeria Sagheddu

Sara Soldi

Affiliations

Soon will be listed here.

Abstract

Recent investigations have highlighted, both experimentally and clinically, that probiotic strains equipped with arabinofuranosidase, in particular and , favor regular intestinal motility, thus counteracting constipation. By analyzing the gene expression and the proliferative response in the presence of arabinan of the probiotic W11, a strain previously validated as an anti-constipation probiotic, we have speculated that its response mechanism to arabinan can effectively explain its clinical action. Our approach could be used in the future to select probiotics endowed with arabinofuranosidase-related anti-constipation effects.

Citing Articles

subsp. TG11 ameliorates loperamide-induced constipation in mice by modulating gut microbiota.

Ma W, Zhao Y, Liu Y, Wang Y, Yu S, Huang L Front Microbiol. 2025; 16:1525887.

PMID: 39944653 PMC: 11813947. DOI: 10.3389/fmicb.2025.1525887.

References

Marzet C, Burgos F, Del Compare M, Gerold I, Tabacco O, Vinderola G . Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Arch Argent Pediatr. 2022; 120(1):e1-e7. DOI: 10.5546/aap.2022.eng.e1. View

Soret R, Chevalier J, de Coppet P, Poupeau G, Derkinderen P, Segain J . Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats. Gastroenterology. 2010; 138(5):1772-82. DOI: 10.1053/j.gastro.2010.01.053. View

Vriesman M, Koppen I, Camilleri M, Di Lorenzo C, Benninga M . Management of functional constipation in children and adults. Nat Rev Gastroenterol Hepatol. 2019; 17(1):21-39. DOI: 10.1038/s41575-019-0222-y. View

Giua C, Romano F, Keber E, Pellegrino P, Perez 3rd M, Uboldi M . A Prospective Real-World Study of Bacillus clausii Evaluating Use, Treatment Habits and Patient Satisfaction in Italian Community Pharmacies: The PEGASO Study. Drugs Real World Outcomes. 2023; 11(1):137-147. PMC: 10928024. DOI: 10.1007/s40801-023-00402-1. View

Graziano T, Amoruso A, Nicola S, Deidda F, Allesina S, Pane M . The Possible Innovative Use of Bifidobacterium longum W11 in Association With Rifaximin: A New Horizon for Combined Approach?. J Clin Gastroenterol. 2016; :S153-S156. DOI: 10.1097/MCG.0000000000000683. View

Lancaster S, Lee-McMullen B, Abbott C, Quijada J, Hornburg D, Park H . Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans. Cell Host Microbe. 2022; 30(6):848-862.e7. PMC: 9187607. DOI: 10.1016/j.chom.2022.03.036. View

Savard P, Roy D . Determination of Differentially Expressed Genes Involved in Arabinoxylan Degradation by Bifidobacterium longum NCC2705 Using Real-Time RT-PCR. Probiotics Antimicrob Proteins. 2016; 1(2):121. DOI: 10.1007/s12602-009-9015-x. View

Pitkala K, Strandberg T, Finne Soveri U, Ouwehand A, Poussa T, Salminen S . Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial. J Nutr Health Aging. 2007; 11(4):305-11. View

Garzon Mora N, Jaramillo A . Effectiveness of Probiotics in Patients With Constipation: A Systematic Review and Meta-Analysis. Cureus. 2024; 16(1):e52013. PMC: 10854359. DOI: 10.7759/cureus.52013. View

10.

Dong M, Wu Y, Zhang M, Chen P, Zhang Z, Wang S . Effect of probiotics intake on constipation in children: an umbrella review. Front Nutr. 2023; 10:1218909. PMC: 10502344. DOI: 10.3389/fnut.2023.1218909. View

11.

Khatri I, Sharma G, Subramanian S . Composite genome sequence of Bacillus clausii, a probiotic commercially available as Enterogermina, and insights into its probiotic properties. BMC Microbiol. 2020; 19(1):307. PMC: 6937992. DOI: 10.1186/s12866-019-1680-7. View

12.

Rao A, Wong B, Camilleri M, Odunsi-Shiyanbade S, McKinzie S, Ryks M . Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. Gastroenterology. 2010; 139(5):1549-58, 1558.e1. PMC: 3189402. DOI: 10.1053/j.gastro.2010.07.052. View

13.

Amenta M, Cascio M, Di Fiore P, Venturini I . Diet and chronic constipation. Benefits of oral supplementation with symbiotic zir fos (Bifidobacterium longum W11 + FOS Actilight). Acta Biomed. 2007; 77(3):157-62. View

14.

Komeno M, Hayamizu H, Fujita K, Ashida H . Two Novel α-l-Arabinofuranosidases from subsp. Belonging to Glycoside Hydrolase Family 43 Cooperatively Degrade Arabinan. Appl Environ Microbiol. 2019; 85(6). PMC: 6414367. DOI: 10.1128/AEM.02582-18. View

15.

Jungersen M, Wind A, Johansen E, Christensen J, Stuer-Lauridsen B, Eskesen D . The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2016; 2(2):92-110. PMC: 5029483. DOI: 10.3390/microorganisms2020092. View

16.

Colecchia A, Vestito A, La Rocca A, Pasqui F, Nikiforaki A, Festi D . Effect of a symbiotic preparation on the clinical manifestations of irritable bowel syndrome, constipation-variant. Results of an open, uncontrolled multicenter study. Minerva Gastroenterol Dietol. 2006; 52(4):349-58. View

17.

Zannini E, Bravo Nunez A, Sahin A, Arendt E . Arabinoxylans as Functional Food Ingredients: A Review. Foods. 2022; 11(7). PMC: 8997659. DOI: 10.3390/foods11071026. View

18.

Pascale N, Gu F, Larsen N, Jespersen L, Respondek F . The Potential of Pectins to Modulate the Human Gut Microbiota Evaluated by In Vitro Fermentation: A Systematic Review. Nutrients. 2022; 14(17). PMC: 9460662. DOI: 10.3390/nu14173629. View

19.

DI Pierro F, Bertuccioli A, Pane M, Ivaldi L . Effects of rifaximin-resistant Bifidobacterium longum W11 in subjects with symptomatic uncomplicated diverticular disease treated with rifaximin. Minerva Gastroenterol Dietol. 2019; 65(4):259-264. DOI: 10.23736/S1121-421X.19.02622-9. View

20.

Van Der Schoot A, Helander C, Whelan K, Dimidi E . Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2022; 41(12):2759-2777. DOI: 10.1016/j.clnu.2022.10.015. View