Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling, and Trismus After Impacted Lower Third Molar Surgery: Randomised Clinical Trial

Overview

Journal Medicina (Kaunas)

Publisher MDPI

Specialty General Medicine

Date 2024 Aug 29

PMID 39202488

Authors

Volkan Kaplan

Levent Cigerim

Erkan Feslihan

Saadet Cinarsoy Cigerim

Affiliations

Soon will be listed here.

Abstract

: The aim of this study was to investigate the efficacy of a single preoperative dose of deflazacort on pain, swelling, and trismus after impacted lower third molar surgery. : This randomised, prospective, double-blind, split-mouth clinical study included 26 healthy individuals with bilaterally impacted lower third molars. Group 1 was given a placebo (single-dose vitamin C tablet), and group 2 was given a single 30 mg dose of deflazacort 1 h prior to surgery. Pain was evaluated using the visual analogue scale for 1 week postoperatively. Oedema (in mm) and trismus (in mm) were evaluated preoperatively and on postoperative days 2 and 7. The Mann-Whitney test was applied for group analyses. values < 0.05 were considered statistically significant. : Postoperative pain scores were significantly lower in the deflazacort group at the 6th and 12th hours after surgery ( < 0.05). There were no significant differences in trismus between the groups at any time point ( > 0.05). There was less oedema in the deflazacort group on postoperative days 2 and 7, without any statistically significant difference ( > 0.05). : A single preoperative dose of 30 mg deflazacort was found to be clinically effective in reducing pain and oedema after extraction of impacted lower third molars.

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References

Minguez-Serra M, Salort-Llorca C, Silvestre-Donat F . Chlorhexidine in the prevention of dry socket: effectiveness of different dosage forms and regimens. Med Oral Patol Oral Cir Bucal. 2009; 14(9):e445-9. View

Waljee A, Rogers M, Lin P, Singal A, Stein J, Marks R . Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ. 2017; 357:j1415. PMC: 6284230. DOI: 10.1136/bmj.j1415. View

Parente L . Deflazacort: therapeutic index, relative potency and equivalent doses versus other corticosteroids. BMC Pharmacol Toxicol. 2017; 18(1):1. PMC: 5216559. DOI: 10.1186/s40360-016-0111-8. View

Sabhlok S, Kenjale P, Mony D, Khatri I, Kumar P . Randomized Controlled Trial to Evaluate the Efficacy of Oral Dexamethasone and Intramuscular Dexamethasone in Mandibular Third Molar Surgeries. J Clin Diagn Res. 2015; 9(11):ZC48-51. PMC: 4668523. DOI: 10.7860/JCDR/2015/13930.6813. View

de Vicente J, Hernandez-Vallejo G, Brana-Abascal P, Pena I . Maxillary sinus augmentation with autologous bone harvested from the lateral maxillary wall combined with bovine-derived hydroxyapatite: clinical and histologic observations. Clin Oral Implants Res. 2010; 21(4):430-8. DOI: 10.1111/j.1600-0501.2009.01877.x. View

Cho H, Lynham A, Hsu E . Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence. Aust Dent J. 2017; 62(4):412-419. DOI: 10.1111/adj.12526. View

Markham A, Bryson H . Deflazacort. A review of its pharmacological properties and therapeutic efficacy. Drugs. 1995; 50(2):317-33. DOI: 10.2165/00003495-199550020-00008. View

Canellas J, Ritto F, Tiwana P . Comparative efficacy and safety of different corticosteroids to reduce inflammatory complications after mandibular third molar surgery: a systematic review and network meta-analysis. Br J Oral Maxillofac Surg. 2022; 60(8):1035-1043. DOI: 10.1016/j.bjoms.2022.05.003. View

Torrejon-Moya A, Saka-Herran C, Izquierdo-Gomez K, Mari-Roig A, Estrugo-Devesa A, Lopez-Lopez J . Oral Lichen Planus and Dental Implants: Protocol and Systematic Review. J Clin Med. 2020; 9(12). PMC: 7767368. DOI: 10.3390/jcm9124127. View

10.

Saravanan K, Kannan R, John R, Nantha Kumar C . A Single Pre Operative Dose of Sub Mucosal Dexamethasone is Effective in Improving Post Operative Quality of Life in the Surgical Management of Impacted Third Molars: A Comparative Randomised Prospective Study. J Maxillofac Oral Surg. 2016; 15(1):67-71. PMC: 4759017. DOI: 10.1007/s12663-015-0795-0. View

11.

Porpiglia F, Destefanis P, Fiori C, Fontana D . Effectiveness of nifedipine and deflazacort in the management of distal ureter stones. Urology. 2000; 56(4):579-82. DOI: 10.1016/s0090-4295(00)00732-9. View

12.

Kapugi M, Cunningham K . Corticosteroids. Orthop Nurs. 2019; 38(5):336-339. DOI: 10.1097/NOR.0000000000000595. View

13.

Bylo M, Farewell R, Coppenrath V, Yogaratnam D . A Review of Deflazacort for Patients With Duchenne Muscular Dystrophy. Ann Pharmacother. 2020; 54(8):788-794. DOI: 10.1177/1060028019900500. View

14.

Selvaraj L, Hanumantha Rao S, Lankupalli A . Comparison of Efficacy of Methylprednisolone Injection into Masseter Muscle Versus Gluteal Muscle for Surgical Removal of Impacted Lower Third Molar. J Maxillofac Oral Surg. 2015; 13(4):495-8. PMC: 4518804. DOI: 10.1007/s12663-013-0562-z. View

15.

Kazancioglu H, Ezirganli S, Demirtas N . Comparison of the influence of ozone and laser therapies on pain, swelling, and trismus following impacted third-molar surgery. Lasers Med Sci. 2013; 29(4):1313-9. DOI: 10.1007/s10103-013-1300-y. View

16.

Chopra D, Rehan H, Mehra P, Kakkar A . A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. Int J Oral Maxillofac Surg. 2009; 38(4):350-5. DOI: 10.1016/j.ijom.2008.12.013. View

17.

Moraschini V, Hidalgo R, Porto Barboza E . Effect of submucosal injection of dexamethasone after third molar surgery: a meta-analysis of randomized controlled trials. Int J Oral Maxillofac Surg. 2015; 45(2):232-40. DOI: 10.1016/j.ijom.2015.09.008. View

18.

Miroshnychenko A, Azab M, Ibrahim S, Roldan Y, Diaz Martinez J, Tamilselvan D . Corticosteroids for managing acute pain subsequent to surgical extraction of mandibular third molars: A systematic review and meta-analysis. J Am Dent Assoc. 2023; 154(8):727-741.e10. PMC: 10910594. DOI: 10.1016/j.adaj.2023.04.018. View

19.

Dilan O, Levent C, Volkan K, Mehmet G, Abdurrahman G, Mohammad A . Evaluation of the effects of silk and polyethylene terephthalate sutures on postoperative complications in impacted lower third molar surgery. J Mater Sci Mater Med. 2023; 34(11):51. PMC: 10579107. DOI: 10.1007/s10856-023-06756-w. View

20.

Antonelli A, Barone S, Bennardo F, Giudice A . Three-dimensional facial swelling evaluation of pre-operative single-dose of prednisone in third molar surgery: a split-mouth randomized controlled trial. BMC Oral Health. 2023; 23(1):614. PMC: 10468892. DOI: 10.1186/s12903-023-03334-y. View