Gene Variants in Components of the MicroRNA Processing Pathway in Chronic Myeloid Leukemia

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2024 Aug 29

PMID 39202414

Authors

Guillermina Chavaro-Francisco

Araceli Hernandez-Zavala

Camila E Bravo-Cidro

Sandybel Rios-Rodriguez

Mabel Mucino-Sanchez

Marisol Lopez-Lopez

Xochitl H Castro-Martinez

Irma Olarte-Carrillo

Anel Garcia-Laguna

Gilberto Barranco-Lampon

Adrian De la Cruz-Rosas

Adolfo Martinez-Tovar

Emilio J Cordova

Affiliations

Soon will be listed here.

Abstract

Current therapy in chronic myeloid leukemia (CML) has improved patient life expectancy close to that of healthy individuals. However, molecular alterations other than BCR::ABL1 fusion gene in CML are barely known. MicroRNAs are important regulators of gene expression, and variants in some of the components of microRNA biosynthesis pathways have been associated with genetic susceptibility to different types of cancer. Thus, the aim of this study was to evaluate the association of variants located in genes involved in the biogenesis of microRNAs with susceptibility to CML. Fifteen variants in eight genes involved in the biogenesis of miRNAs were genotyped in 296 individuals with CML and 485 healthy participants using TaqMan probes. The association of gene variants with CML and clinical variables was evaluated by a Chi-square test, and odds ratios and 95% confidence intervals were estimated by logistic regression. The variant rs13078 in was significantly higher among CML individuals than in healthy participants. In addition, the variants rs7813 and rs2740349 were significantly associated with worse prognosis, according to their Hasford scores, whereas the rs2740349 variant was also associated with a later age at diagnosis. These findings suggest that variants in components of the microRNA biogenesis pathway could be involved in CML genetic risk.

References

de Kock L, Wang Y, Revil T, Badescu D, Rivera B, Sabbaghian N . High-sensitivity sequencing reveals multi-organ somatic mosaicism causing DICER1 syndrome. J Med Genet. 2015; 53(1):43-52. DOI: 10.1136/jmedgenet-2015-103428. View

Zhang L, Truong Nguyen L, Chen Y, Wu D, Cook G, Hoang D . Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance. Nat Commun. 2021; 12(1):6154. PMC: 8536759. DOI: 10.1038/s41467-021-26420-7. View

Hill D, Ivanovich J, Priest J, Gurnett C, Dehner L, Desruisseau D . DICER1 mutations in familial pleuropulmonary blastoma. Science. 2009; 325(5943):965. PMC: 3098036. DOI: 10.1126/science.1174334. View

Borghini A, Pulignani S, Mercuri A, Vecoli C, Turchi S, Carpeggiani C . Influence of genetic polymorphisms in DICER and XPO5 genes on the risk of coronary artery disease and circulating levels of vascular miRNAs. Thromb Res. 2019; 180:32-36. DOI: 10.1016/j.thromres.2019.05.021. View

Sung H, Yang H, Zhang H, Yang Q, Hu N, Tang Z . Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers. Int J Epidemiol. 2015; 44(4):1341-52. PMC: 4598798. DOI: 10.1093/ije/dyv050. View

Bower H, Bjorkholm M, Dickman P, Hoglund M, Lambert P, Andersson T . Life Expectancy of Patients With Chronic Myeloid Leukemia Approaches the Life Expectancy of the General Population. J Clin Oncol. 2016; 34(24):2851-7. DOI: 10.1200/JCO.2015.66.2866. View

Liu J, Liu J, Wei M, He Y, Liao B, Liao G . Genetic variants in the microRNA machinery gene GEMIN4 are associated with risk of prostate cancer: a case-control study of the Chinese Han population. DNA Cell Biol. 2012; 31(7):1296-302. PMC: 3391491. DOI: 10.1089/dna.2011.1600. View

Grelier G, Voirin N, Ay A, Cox D, Chabaud S, Treilleux I . Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Br J Cancer. 2009; 101(4):673-83. PMC: 2736830. DOI: 10.1038/sj.bjc.6605193. View

Osuch-Wojcikiewicz E, Bruzgielewicz A, Niemczyk K, Sieniawska-Buccella O, Nowak A, Walczak A . Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population. Biomed Res Int. 2015; 2015:298378. PMC: 4673325. DOI: 10.1155/2015/298378. View

10.

Kozomara A, Birgaoanu M, Griffiths-Jones S . miRBase: from microRNA sequences to function. Nucleic Acids Res. 2018; 47(D1):D155-D162. PMC: 6323917. DOI: 10.1093/nar/gky1141. View

11.

Kim M, Kim J, Lee S, Park H, Lee J, Rim K . Variation in the Dicer and RAN Genes Are Associated with Survival in Patients with Hepatocellular Carcinoma. PLoS One. 2016; 11(9):e0162279. PMC: 5017754. DOI: 10.1371/journal.pone.0162279. View

12.

Aldhalaan H, AlBakheet A, AlRuways S, Almutairi N, AlNakiyah M, AlGhofaili R . A Novel Variant in a Consanguineous Family Leads to Neurodevelopmental Impairment with Severe Microcephaly, Spastic Quadriplegia, Epilepsy, and Cataracts. Genes (Basel). 2022; 13(1). PMC: 8774908. DOI: 10.3390/genes13010092. View

13.

Cheng H, Li H, Feng Y, Zhang Z . Correlation analysis between SNPs in microRNA-machinery genes and tuberculosis susceptibility in the Chinese Uygur population. Medicine (Baltimore). 2018; 97(52):e13637. PMC: 6314764. DOI: 10.1097/MD.0000000000013637. View

14.

Basak J, Piotrzkowska D, Majsterek I, Kucharska E . Relationship between the Occurrence of Genetic Variants of Single Nucleotide Polymorphism in microRNA Processing Genes and the Risk of Developing Multiple Sclerosis. Biomedicines. 2022; 10(12). PMC: 9776367. DOI: 10.3390/biomedicines10123124. View

15.

Guo S, Peng Z, Yang X, Fan K, Ye H, Li Z . miR-148a promoted cell proliferation by targeting p27 in gastric cancer cells. Int J Biol Sci. 2011; 7(5):567-74. PMC: 3088878. DOI: 10.7150/ijbs.7.567. View

16.

Fu Z, Wang L, Li S, Chen F, Au-Yeung K, Shi C . MicroRNA as an Important Target for Anticancer Drug Development. Front Pharmacol. 2021; 12:736323. PMC: 8425594. DOI: 10.3389/fphar.2021.736323. View

17.

Kowalczyk M, Kowalczyk E, Gogolewska M, Skrzypek M, Talarowska M, Majsterek I . Association of polymorphic variants in GEMIN genes with the risk of depression in a Polish population. PeerJ. 2022; 10:e14317. PMC: 9673762. DOI: 10.7717/peerj.14317. View

18.

Moghbelinejad S, Najafipour R, Momeni A . Association of rs1057035polymorphism in microRNA biogenesis pathway gene (DICER1) with azoospermia among Iranian population. Genes Genomics. 2018; 40(1):17-24. DOI: 10.1007/s13258-017-0605-9. View

19.

Karube Y, Tanaka H, Osada H, Tomida S, Tatematsu Y, Yanagisawa K . Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci. 2005; 96(2):111-5. PMC: 11158408. DOI: 10.1111/j.1349-7006.2005.00015.x. View

20.

Mohr A, Mott J . Overview of microRNA biology. Semin Liver Dis. 2015; 35(1):3-11. PMC: 4797991. DOI: 10.1055/s-0034-1397344. View