Analysis of the Molecular Mechanism of Energy Metabolism in the Sex Differentiation of Chickens Based on Transcriptome Sequencing

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2024 Aug 29

PMID 39202395

Authors

Ziduo Zhao

Zongyi Zhao

Fufu Cheng

Zhe Wang

Qingqing Geng

Yingjie Wang

Yingjie Niu

Qisheng Zuo

Yani Zhang

Affiliations

Soon will be listed here.

Abstract

The determination of sex in mammals is established and controlled by various complex mechanisms. In contrast, sex control in poultry remains an unresolved issue. In this study, RNA-sequencing was conducted for male gonads and ovarian tissues in chicken embryos of up to 18.5 days to identify metabolic factors influencing male and female sex differentiation, as well as gonadal development. Our results reveal that , a critical glycolysis-related protein, plays a significant role in chicken sex differentiation via , a crucial hormone gene. We propose that our discoveries bolster the notion that glycolysis and oxidative phosphorylation function as antecedent contributors to sexual phenotypic development and preservation.

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