Therapeutic Implication of MiRNAs As an Active Regulatory Player in the Management of Pain: A Review

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2024 Aug 29

PMID 39202362

Authors

Mubashir Hassan

Saba Shahzadi

Muhammad Yasir

Wanjoo Chun

Andrzej Kloczkowski

Affiliations

Soon will be listed here.

Abstract

Chronic pain is frequently associated with neuropathy, inflammation, or the malfunctioning of nerves. Chronic pain is associated with a significant burden of morbidity due to opioid use, associated with addiction and tolerance, and disability. MicroRNAs (miRs) are emerging therapeutic targets to treat chronic pain through the regulation of genes associated with inflammation, neuronal excitability, survival, or de-differentiation. In this review, we discuss the possible involvement of miRs in pain-related molecular pathways. miRs are known to regulate high-conviction pain genes, supporting their potential as therapeutic targets.

References

Tsuda M, Koga K, Chen T, Zhuo M . Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex. J Neurochem. 2017; 141(4):486-498. DOI: 10.1111/jnc.14001. View

Gupta A, Jakobsson J . Acetaminophen, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 selective inhibitors: an update. Plast Reconstr Surg. 2014; 134(4 Suppl 2):24S-31S. DOI: 10.1097/PRS.0000000000000672. View

Kynast K, Russe O, Geisslinger G, Niederberger E . Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets. Expert Rev Neurother. 2013; 13(5):515-25. DOI: 10.1586/ern.13.34. View

Mercadante S . Opioid Analgesics Adverse Effects: The Other Side of the Coin. Curr Pharm Des. 2019; 25(30):3197-3202. DOI: 10.2174/1381612825666190717152226. View

Lutz B, Bekker A, Tao Y . Noncoding RNAs: new players in chronic pain. Anesthesiology. 2014; 121(2):409-17. PMC: 4110167. DOI: 10.1097/ALN.0000000000000265. View

Maharshak N, Shenhar-Tsarfaty S, Aroyo N, Orpaz N, Guberman I, Canaani J . MicroRNA-132 modulates cholinergic signaling and inflammation in human inflammatory bowel disease. Inflamm Bowel Dis. 2013; 19(7):1346-53. DOI: 10.1097/MIB.0b013e318281f47d. View

Becker W, Sullivan L, Tetrault J, Desai R, Fiellin D . Non-medical use, abuse and dependence on prescription opioids among U.S. adults: psychiatric, medical and substance use correlates. Drug Alcohol Depend. 2007; 94(1-3):38-47. DOI: 10.1016/j.drugalcdep.2007.09.018. View

Zhang J, Banerjee B . Role of MicroRNA in Visceral Pain. J Neurogastroenterol Motil. 2015; 21(2):159-71. PMC: 4398244. DOI: 10.5056/jnm15027. View

DMello R, Dickenson A . Spinal cord mechanisms of pain. Br J Anaesth. 2008; 101(1):8-16. DOI: 10.1093/bja/aen088. View

10.

Frances R, Mata-Garrido J, de la Fuente R, Carcelen M, Lafarga M, Berciano M . Identification of Epigenetic Interactions between MicroRNA-30c-5p and DNA Methyltransferases in Neuropathic Pain. Int J Mol Sci. 2022; 23(22). PMC: 9694031. DOI: 10.3390/ijms232213994. View

11.

Garzon R, Marcucci G, Croce C . Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov. 2010; 9(10):775-89. PMC: 3904431. DOI: 10.1038/nrd3179. View

12.

Dykes I, Emanueli C . Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA. Genomics Proteomics Bioinformatics. 2017; 15(3):177-186. PMC: 5487525. DOI: 10.1016/j.gpb.2016.12.005. View

13.

Brown R, Zuelsdorff M, Fleming M . Adverse effects and cognitive function among primary care patients taking opioids for chronic nonmalignant pain. J Opioid Manag. 2007; 2(3):137-46. DOI: 10.5055/jom.2006.0023. View

14.

Burrows K, Figueroa-Hall L, Alarbi A, Stewart J, Kuplicki R, Tan C . Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals. Brain Behav Immun Health. 2023; 27:100582. PMC: 9807827. DOI: 10.1016/j.bbih.2022.100582. View

15.

Swieboda P, Filip R, Prystupa A, Drozd M . Assessment of pain: types, mechanism and treatment. Ann Agric Environ Med. 2014; Spec no. 1:2-7. View

16.

Tigerholm J, Poulsen A, Andersen O, Morch C . From Perception Threshold to Ion Channels-A Computational Study. Biophys J. 2019; 117(2):281-295. PMC: 6700668. DOI: 10.1016/j.bpj.2019.04.041. View

17.

Liao X, Mao W, Wang Q, Yang G, Wu W, Shao S . MicroRNA-24 inhibits serotonin reuptake transporter expression and aggravates irritable bowel syndrome. Biochem Biophys Res Commun. 2015; 469(2):288-93. DOI: 10.1016/j.bbrc.2015.11.102. View

18.

Kojima T, Takano K, Yamamoto T, Murata M, Son S, Imamura M . Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes. Liver Int. 2007; 28(4):534-45. DOI: 10.1111/j.1478-3231.2007.01631.x. View

19.

Hackel D, Krug S, Sauer R, Mousa S, Bocker A, Pflucke D . Transient opening of the perineurial barrier for analgesic drug delivery. Proc Natl Acad Sci U S A. 2012; 109(29):E2018-27. PMC: 3406837. DOI: 10.1073/pnas.1120800109. View

20.

Zhang J, Yu J, Kannampalli P, Nie L, Meng H, Medda B . MicroRNA-mediated downregulation of potassium-chloride-cotransporter and vesicular γ-aminobutyric acid transporter expression in spinal cord contributes to neonatal cystitis-induced visceral pain in rats. Pain. 2017; 158(12):2461-2474. PMC: 5680103. DOI: 10.1097/j.pain.0000000000001057. View