Bioinformatics Analysis of the Genome of IEGM 1362, an (-)-Isopulegol Biotransformer

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2024 Aug 29

PMID 39202353

Authors

Polina Yu Maltseva

Natalia A Plotnitskaya

Anastasiia V Krivoruchko

Aleksey V Beletskiy

Andrey L Rakitin

Andrey V Mardanov

Irina B Ivshina

Affiliations

Soon will be listed here.

Abstract

A genome of IEGM 1362 was sequenced and annotated. This strain can transform monoterpene alcohol (-)-isopulegol with the formation of two novel pharmacologically promising metabolites. Nine genes encoding cytochrome P450, presumably involved in (-)-isopulegol transformation, were found in the genome of IEGM 1362. Primers and PCR conditions for their detection were selected. The obtained data can be used for the further investigation of genes encoding enzymes involved in monoterpene biotransformation.

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