Role of Extracellular Vesicles in Crohn's Patients on Adalimumab Who Received COVID-19 Vaccination

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Aug 29

PMID 39201543

Authors

Maria De Luca

Biagia Musio

Francesco Balestra

Valentina Arre

Roberto Negro

Nicoletta Depalo

Federica Rizzi

Rita Mastrogiacomo

Giorgia Panzetta

Rossella Donghia

Pasqua Letizia Pesole

Sergio Coletta

Emanuele Piccinno

Viviana Scalavino

Grazia Serino

Fatima Maqoud

Francesco Russo

Antonella Orlando

Stefano Todisco

Pietro Mastrorilli

Maria Lucia Curri

Vito Gallo

Gianluigi Giannelli

Maria Principia Scavo

Affiliations

Soon will be listed here.

Abstract

Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) affecting the gastrointestinal tract that can also cause extra-intestinal complications. Following exposure to the mRNA vaccine BNT162b2 (Pfizer-BioNTech) encoding the SARS-CoV-2 Spike (S) protein, some patients experienced a lack of response to the biological drug Adalimumab and a recrudescence of the disease. In CD patients in progression, resistant to considered biological therapy, an abnormal increase in intestinal permeability was observed, more often with a modulated expression of different proteins such as Aquaporin 8 (AQP8) and in tight junctions (e.g., ZO-1, Claudin1, Claudin2, Occludin), especially during disease flares. The aim of this study is to investigate how the SARS-CoV-2 vaccine could interfere with IBD therapy and contribute to disease exacerbation. We investigated the role of the SARS-CoV-2 Spike protein, transported by extracellular vesicles (EVs), and the impact of various EVs components, namely, exosomes (EXOs) and microvesicles (MVs), in modulating the expression of molecules involved in the exacerbation of CD, which remains unknown.

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