Association of Gene Polymorphisms and Haplotypes with Acute Heart Rate Response to Exercise

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Aug 29

PMID 39201274

Authors

Habib Al Ashkar

Nora Kovacs

Ilona Veres-Balajti

Roza Adany

Peter Piko

Affiliations

Soon will be listed here.

Abstract

Polymorphisms in the cholesteryl ester transfer protein () gene are known to be strongly associated with increased cardiovascular risk, primarily through their effects on the lipid profile and consequently on atherosclerotic risk. The acute heart rate response (AHRR) to physical activity is closely related to individual cardiovascular health. This study aimed to investigate the effect of gene polymorphisms on AHRR. Our analysis examines the association of five single nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the gene with AHRR in 607 people from the Hungarian population. Individual AHRR in the present study was assessed using the YMCA 3-min step test and was estimated as the difference between resting and post-exercise heart rate, i.e., delta heart rate (ΔHR). To exclude the direct confounding effect of the gene on the lipid profile, adjustments for TG and HDL-C levels, next to conventional risk factors, were applied in the statistical analyses. Among the examined five SNPs, two showed a significant association with lower ΔHR (rs1532624-C: B = -8.41, < 0.001; rs708272-G: B = -8.33, < 0.001) and reduced the risk of adverse AHRR (rs1532624-C: OR = 0.44, = 0.004; rs708272-G: OR = 0.43, = 0.003). Among the ten haplotypes, two showed significant association with lower ΔHR (H3-CAGCA: B = -6.81, = 0.003; H9-CGGCG: B = -14.64, = 0.015) and lower risk of adverse AHRR (H3-CAGCA: OR = 0.58, = 0.040; H9-CGGCG: OR = 0.05, = 0.009) compared to the reference haplotype (H1-AGACG). Our study is the first to report a significant association between gene polymorphisms and AHRR. It also confirms that the association of the gene with cardiovascular risk is mediated by changes in heart rate in response to physical activity, in addition to its effect on lipid profile.

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