Clinical Updates in Coronary Artery Disease: A Comprehensive Review

Overview

Journal J Clin Med

Specialty General Medicine

Date 2024 Aug 29

PMID 39200741

Authors

Andrea Bottardi

Guy F A Prado

Mattia Lunardi

Simone Fezzi

Gabriele Pesarini

Domenico Tavella

Roberto Scarsini

Flavio Ribichini

Affiliations

Soon will be listed here.

Abstract

Despite significant goals achieved in diagnosis and treatment in recent decades, coronary artery disease (CAD) remains a high mortality entity and continues to pose substantial challenges to healthcare systems globally. After the latest guidelines, novel data have emerged and have not been yet considered for routine practice. The scope of this review is to go beyond the guidelines, providing insights into the most recent clinical updates in CAD, focusing on non-invasive diagnostic techniques, risk stratification, medical management and interventional therapies in the acute and stable scenarios. Highlighting and synthesizing the latest developments in these areas, this review aims to contribute to the understanding and management of CAD helping healthcare providers worldwide.

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References

Kapur A, Malik I, Bagger J, ANDERSON J, Kooner J, Thomas M . The Coronary Artery Revascularisation in Diabetes (CARDia) trial: background, aims, and design. Am Heart J. 2005; 149(1):13-9. DOI: 10.1016/j.ahj.2004.07.001. View

Ray K, Wright R, Kallend D, Koenig W, Leiter L, Raal F . Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol. N Engl J Med. 2020; 382(16):1507-1519. DOI: 10.1056/NEJMoa1912387. View

Ahn J, Roh J, Kim Y, Park D, Yun S, Lee P . Randomized Trial of Stents Versus Bypass Surgery for Left Main Coronary Artery Disease: 5-Year Outcomes of the PRECOMBAT Study. J Am Coll Cardiol. 2015; 65(20):2198-206. DOI: 10.1016/j.jacc.2015.03.033. View

Leonard J, Rahouma M, Abouarab A, Schwann A, Scuderi G, Lau C . Totally endoscopic coronary artery bypass surgery: A meta-analysis of the current evidence. Int J Cardiol. 2018; 261:42-46. DOI: 10.1016/j.ijcard.2017.12.071. View

Hundley W, Bluemke D, Finn J, Flamm S, Fogel M, Friedrich M . ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol. 2010; 55(23):2614-62. PMC: 3042771. DOI: 10.1016/j.jacc.2009.11.011. View

Mehta S, Granger C, Eikelboom J, Bassand J, Wallentin L, Faxon D . Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial. J Am Coll Cardiol. 2007; 50(18):1742-51. DOI: 10.1016/j.jacc.2007.07.042. View

Mohri M, Koyanagi M, Egashira K, Tagawa H, Ichiki T, Shimokawa H . Angina pectoris caused by coronary microvascular spasm. Lancet. 1998; 351(9110):1165-9. DOI: 10.1016/S0140-6736(97)07329-7. View

Saito S, Bennett J, Nef H, Webster M, Namiki A, Takahashi A . First randomised controlled trial comparing the sirolimus-eluting bioadaptor with the zotarolimus-eluting drug-eluting stent in patients with coronary artery lesions: 12-month clinical and imaging data from the multi-centre, international,.... EClinicalMedicine. 2023; 65:102304. PMC: 10725075. DOI: 10.1016/j.eclinm.2023.102304. View

Cortese B, di Palma G, Garcia Guimaraes M, Piraino D, Orrego P, Buccheri D . Drug-Coated Balloon Versus Drug-Eluting Stent for Small Coronary Vessel Disease: PICCOLETO II Randomized Clinical Trial. JACC Cardiovasc Interv. 2020; 13(24):2840-2849. DOI: 10.1016/j.jcin.2020.08.035. View

10.

Harrington R, Stone G, McNulty S, White H, Lincoff A, Gibson C . Platelet inhibition with cangrelor in patients undergoing PCI. N Engl J Med. 2009; 361(24):2318-29. DOI: 10.1056/NEJMoa0908628. View

11.

DAgostino Sr R, Vasan R, Pencina M, Wolf P, Cobain M, Massaro J . General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation. 2008; 117(6):743-53. DOI: 10.1161/CIRCULATIONAHA.107.699579. View

12.

Williams M, Moss A, Dweck M, Hunter A, Pawade T, Adamson P . Standardized reporting systems for computed tomography coronary angiography and calcium scoring: A real-world validation of CAD-RADS and CAC-DRS in patients with stable chest pain. J Cardiovasc Comput Tomogr. 2019; 14(1):3-11. DOI: 10.1016/j.jcct.2019.07.010. View

13.

Thiele H, Akin I, Sandri M, Fuernau G, de Waha S, Meyer-Saraei R . PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock. N Engl J Med. 2017; 377(25):2419-2432. DOI: 10.1056/NEJMoa1710261. View

14.

Wacker C, Bock M, Hartlep A, Beck G, van Kaick G, Ertl G . Changes in myocardial oxygenation and perfusion under pharmacological stress with dipyridamole: assessment using T*2 and T1 measurements. Magn Reson Med. 1999; 41(4):686-95. DOI: 10.1002/(sici)1522-2594(199904)41:4<686::aid-mrm6>3.0.co;2-9. View

15.

Verberne H, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P . EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision. Eur J Nucl Med Mol Imaging. 2015; 42(12):1929-40. PMC: 4589547. DOI: 10.1007/s00259-015-3139-x. View

16.

Spertus J, Jones P, Maron D, OBrien S, Reynolds H, Rosenberg Y . Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease. N Engl J Med. 2020; 382(15):1408-1419. PMC: 7261489. DOI: 10.1056/NEJMoa1916370. View

17.

Carson P, Wertheimer J, Miller A, OConnor C, Pina I, Selzman C . The STICH trial (Surgical Treatment for Ischemic Heart Failure): mode-of-death results. JACC Heart Fail. 2014; 1(5):400-8. PMC: 3829618. DOI: 10.1016/j.jchf.2013.04.012. View

18.

Hong S, Kim B, Cho I, Kim H, Rha S, Lee S . Effect of Coronary CTA on Chronic Total Occlusion Percutaneous Coronary Intervention: A Randomized Trial. JACC Cardiovasc Imaging. 2021; 14(10):1993-2004. DOI: 10.1016/j.jcmg.2021.04.013. View

19.

Rathod K, Koganti S, Jain A, Astroulakis Z, Lim P, Rakhit R . Complete Versus Culprit-Only Lesion Intervention in Patients With Acute Coronary Syndromes. J Am Coll Cardiol. 2018; 72(17):1989-1999. DOI: 10.1016/j.jacc.2018.07.089. View

20.

Ahn J, Kang D, Yun S, Hur S, Park H, Tresukosol D . Everolimus-Eluting Stents or Bypass Surgery for Multivessel Coronary Artery Disease: Extended Follow-Up Outcomes of Multicenter Randomized Controlled BEST Trial. Circulation. 2022; 146(21):1581-1590. DOI: 10.1161/CIRCULATIONAHA.122.062188. View