Multidrug-Resistant Colonizing Pigs and Farm Workers in Rio De Janeiro State, Brazil: Potential Interspecies Transmission of Livestock-Associated MRSA (LA-MRSA) ST398

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2024 Aug 29

PMID 39200067

Authors

Joana Talim

Ianick Martins

Cassio Messias

Hellen Sabino

Laura Oliveira

Tatiana Pinto

Julia Albuquerque

Aloysio Cerqueira

Italo Dolores

Beatriz Moreira

Renato Silveira

Felipe Neves

Renata Rabello

Affiliations

Soon will be listed here.

Abstract

Multidrug-resistant (MDR) has been increasingly isolated from pigs and people in close contact with them, especially livestock-associated methicillin-resistant (LA-MRSA). In this cross-sectional study, we investigated colonization in pigs and farm workers, their resistance profile, and genetic background to estimate interspecies transmission potential within farms from Rio de Janeiro state, Brazil, between 2014 and 2019. We collected nasal swabs from 230 pigs and 27 workers from 16 and 10 farms, respectively. Five MDR strains were subjected to whole genome sequencing. Fourteen (6.1%) pigs and seven (25.9%) humans were colonized with , mostly (64-71%) MDR strains. Resistance to clindamycin, erythromycin, penicillin, and tetracycline was the most common among the pig and human strains investigated. MDR strains shared several resistance genes [, G, , (E), and (M)]. Pig and human strains recovered from the same farm shared the same genetic background and antimicrobial resistance profile. LA-MRSA ST398-SCCV-t011 was isolated from pigs in two farms and from a farm worker in one of them, suggesting interspecies transmission. The association between pig management practices and MDR colonization might be investigated in additional studies.

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