Effect of Early Ciprofloxacin Administration on Growth Performance, Meat Quality, Food Safety, and Metabolomic Profiles in Xueshan Chickens

Overview

Journal Animals (Basel)

Date 2024 Aug 29

PMID 39199929

Authors

Lan Huang

Jialuo Sun

Qixin Guo

Yong Jiang

Bai Hao

Guobin Chang

Affiliations

Soon will be listed here.

Abstract

To investigate the effects of early administration of ciprofloxacin (CIP) on Xueshan chickens, in this study Xueshan chickens were measured for growth performance, tested for drug residues, evaluated for meat quality, and muscle metabolism changes were explored using a non-target metabolomics approach. Experimental findings revealed that early CIP use did not significantly impact the overall growth rate of Xueshan chickens ( > 0.05). However, notable alterations in meat quality were observed: the CIP-treated group exhibited a significant decrease in muscle pH (pH and pH) and a marked increase in drip loss and moisture content ( > 0.05). No CIP residues were detected in muscle tissue. Untargeted metabolomics analyses unveiled significant alterations in the metabolic profile of market-age chickens following CIP treatment. Both functional enrichment and metabolic network analyses indicated significant effects on the ko01120 (microbial metabolism in diverse environments) and ko00350 (tyrosine metabolism) pathways, implying that CIP treatment may influence chicken meat quality by modulating microbial communities and amino acid metabolism. This study provides a crucial foundation for understanding the impact of antibiotics on meat quality and metabolism in poultry production, offering scientific insights for optimizing antibiotic-use strategies and safeguarding poultry product quality.

References

Plata G, Baxter N, Susanti D, Volland-Munson A, Gangaiah D, Nagireddy A . Growth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome. Commun Biol. 2022; 5(1):293. PMC: 8975857. DOI: 10.1038/s42003-022-03239-6. View

Subirats J, Murray R, Yin X, Zhang T, Topp E . Impact of chicken litter pre-application treatment on the abundance, field persistence, and transfer of antibiotic resistant bacteria and antibiotic resistance genes to vegetables. Sci Total Environ. 2021; 801:149718. DOI: 10.1016/j.scitotenv.2021.149718. View

Sun S, Shen J, Li D, Li B, Sun X, Ma L . A new insight into the ARG association with antibiotics and non-antibiotic agents-antibiotic resistance and toxicity. Environ Pollut. 2021; 293:118524. DOI: 10.1016/j.envpol.2021.118524. View

Moraru R, Pourcher A, Jadas-Hecart A, Kempf I, Ziebal C, Kervarrec M . Changes in concentrations of fluoroquinolones and of ciprofloxacin-resistant Enterobacteriaceae in chicken feces and manure stored in a heap. J Environ Qual. 2012; 41(3):754-63. DOI: 10.2134/jeq2011.0313. View

Kanehisa M . Molecular network analysis of diseases and drugs in KEGG. Methods Mol Biol. 2012; 939:263-75. DOI: 10.1007/978-1-62703-107-3_17. View

Mir N, Rafiq A, Kumar F, Singh V, Shukla V . Determinants of broiler chicken meat quality and factors affecting them: a review. J Food Sci Technol. 2017; 54(10):2997-3009. PMC: 5603000. DOI: 10.1007/s13197-017-2789-z. View

Langfelder P, Horvath S . Fast R Functions for Robust Correlations and Hierarchical Clustering. J Stat Softw. 2012; 46(11). PMC: 3465711. View

Zhang Y, Cheng D, Xie J, Zhang Y, Wan Y, Zhang Y . Impacts of farmland application of antibiotic-contaminated manures on the occurrence of antibiotic residues and antibiotic resistance genes in soil: A meta-analysis study. Chemosphere. 2022; 300:134529. DOI: 10.1016/j.chemosphere.2022.134529. View

Li J, Yin L, Wang L, Li J, Huang P, Yang H . Effects of vitamin B6 on growth, diarrhea rate, intestinal morphology, function, and inflammatory factors expression in a high-protein diet fed to weaned piglets1. J Anim Sci. 2019; 97(12):4865-4874. PMC: 6915213. DOI: 10.1093/jas/skz338. View

10.

Ayandiran T, Falgenhauer L, Schmiedel J, Chakraborty T, Ayeni F . High resistance to tetracycline and ciprofloxacin in bacteria isolated from poultry farms in Ibadan, Nigeria. J Infect Dev Ctries. 2020; 12(6):462-470. DOI: 10.3855/jidc.9862. View

11.

Pearce K, Rosenvold K, Andersen H, Hopkins D . Water distribution and mobility in meat during the conversion of muscle to meat and ageing and the impacts on fresh meat quality attributes--a review. Meat Sci. 2011; 89(2):111-24. DOI: 10.1016/j.meatsci.2011.04.007. View

12.

Wang Y, Li W, Zhang C, Li F, Yang H, Wang Z . Metabolomic comparison of meat quality and metabolites of geese breast muscle at different ages. Food Chem X. 2023; 19:100775. PMC: 10534087. DOI: 10.1016/j.fochx.2023.100775. View

13.

OKeefe J, OKeefe E, Lavie C . Omega-3: The Overlooked Evidence-Based Therapy for Heart Failure. JACC Heart Fail. 2022; 10(4):235-237. DOI: 10.1016/j.jchf.2022.02.004. View

14.

Kim J, Ahn J . Emergence and spread of antibiotic-resistant foodborne pathogens from farm to table. Food Sci Biotechnol. 2022; 31(12):1481-1499. PMC: 9435411. DOI: 10.1007/s10068-022-01157-1. View

15.

Gomez-Gomez C, Blanco-Picazo P, Brown-Jaque M, Quiros P, Rodriguez-Rubio L, Cerda-Cuellar M . Infectious phage particles packaging antibiotic resistance genes found in meat products and chicken feces. Sci Rep. 2019; 9(1):13281. PMC: 6746790. DOI: 10.1038/s41598-019-49898-0. View

16.

Wilson M, Plecko B, Mills P, Clayton P . Disorders affecting vitamin B metabolism. J Inherit Metab Dis. 2019; 42(4):629-646. DOI: 10.1002/jimd.12060. View

17.

Yuan C, Jiang Y, Wang Z, Chen G, Bai H, Chang G . Indigenous, Yellow-Feathered Chickens Body Measurements, Carcass Traits, and Meat Quality Depending on Marketable Age. Animals (Basel). 2022; 12(18). PMC: 9495107. DOI: 10.3390/ani12182422. View

18.

Bendall J, Swatland H . A review of the relationships of pH with physical aspects of pork quality. Meat Sci. 2011; 24(2):85-126. DOI: 10.1016/0309-1740(88)90052-6. View

19.

Sanchez C, Colson C, Gautier N, Noser P, Salvi J, Villet M . Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. Brain Behav Immun. 2024; 117:330-346. DOI: 10.1016/j.bbi.2024.01.216. View

20.

Song L, Jiang G, Wang C, Ma J, Chen H . Effects of antibiotics consumption on the behavior of airborne antibiotic resistance genes in chicken farms. J Hazard Mater. 2022; 437:129288. DOI: 10.1016/j.jhazmat.2022.129288. View