Restoring PKP2 in Arrhythmogenic Cardiomyopathy
Overview
Overview
Journal
Nat Cardiovasc Res
Publisher
Springer Nature
Specialty
Cardiology & Vascular Diseases
Date
2024 Aug 28
PMID
39196151
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
References
1.
Perez-Hernandez M, Marron-Linares G, Schlamp F, Heguy A, van Opbergen C, Mezzano V
. Transcriptomic Coupling of PKP2 With Inflammatory and Immune Pathways Endogenous to Adult Cardiac Myocytes. Front Physiol. 2021; 11:623190.
PMC: 7849609.
DOI: 10.3389/fphys.2020.623190.
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2.
Oxford E, Musa H, Maass K, Coombs W, Taffet S, Delmar M
. Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells. Circ Res. 2007; 101(7):703-11.
DOI: 10.1161/CIRCRESAHA.107.154252.
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3.
Sato P, Musa H, Coombs W, Guerrero-Serna G, Patino G, Taffet S
. Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ Res. 2009; 105(6):523-6.
PMC: 2742576.
DOI: 10.1161/CIRCRESAHA.109.201418.
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4.
Gerull B, Heuser A, Wichter T, Paul M, Basson C, McDermott D
. Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet. 2004; 36(11):1162-4.
DOI: 10.1038/ng1461.
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5.
Cerrone M, Noorman M, Lin X, Chkourko H, Liang F, van der Nagel R
. Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency. Cardiovasc Res. 2012; 95(4):460-8.
PMC: 3422082.
DOI: 10.1093/cvr/cvs218.
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