Microfluidic Preparation of Optical Sensors for Biomedical Applications

Overview

Journal Smart Med

Publisher Wiley

Specialty Biomedical Engineering

Date 2024 Aug 27

PMID 39188556

Authors

Qiao Wang

Chong Wang

Xinyuan Yang

Jiali Wang

Zhuohao Zhang

Luoran Shang

Affiliations

Soon will be listed here.

Abstract

Optical biosensors are platforms that translate biological information into detectable optical signals, and have extensive applications in various fields due to their characteristics of high sensitivity, high specificity, dynamic sensing, etc. The development of optical sensing materials is an important part of optical sensors. In this review, we emphasize the role of microfluidic technology in the preparation of optical sensing materials and the application of the derived optical sensors in the biomedical field. We first present some common optical sensing mechanisms and the functional responsive materials involved. Then, we describe the preparation of these sensing materials by microfluidics. Afterward, we enumerate the biomedical applications of these optical materials as biosensors in disease diagnosis, drug evaluation, and organ-on-a-chip. Finally, we discuss the challenges and prospects in this field.

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References

Zhou Z, Yang Z, Xia L, Zhang H . Construction of an enzyme-based all-fiber SPR biosensor for detection of enantiomers. Biosens Bioelectron. 2021; 198:113836. DOI: 10.1016/j.bios.2021.113836. View

Shang L, Cheng Y, Zhao Y . Emerging Droplet Microfluidics. Chem Rev. 2017; 117(12):7964-8040. DOI: 10.1021/acs.chemrev.6b00848. View

Farzin L, Shamsipur M, Samandari L, Sheibani S . HIV biosensors for early diagnosis of infection: The intertwine of nanotechnology with sensing strategies. Talanta. 2019; 206:120201. DOI: 10.1016/j.talanta.2019.120201. View

Wang Y, He L, Huang K, Chen Y, Wang S, Liu Z . Recent advances in nanomaterial-based electrochemical and optical sensing platforms for microRNA assays. Analyst. 2019; 144(9):2849-2866. DOI: 10.1039/c9an00081j. View

Bi S, Shao D, Yuan Y, Zhao R, Li X . Sensitive surface-enhanced Raman spectroscopy (SERS) determination of nitrofurazone by β-cyclodextrin-protected AuNPs/γ-AlO nanoparticles. Food Chem. 2021; 370:131059. DOI: 10.1016/j.foodchem.2021.131059. View

Berlanda S, Breitfeld M, Dietsche C, Dittrich P . Recent Advances in Microfluidic Technology for Bioanalysis and Diagnostics. Anal Chem. 2020; 93(1):311-331. DOI: 10.1021/acs.analchem.0c04366. View

Bian F, Sun L, Chen H, Wang Y, Wang L, Shang L . Bioinspired Perovskite Nanocrystals-Integrated Photonic Crystal Microsphere Arrays for Information Security. Adv Sci (Weinh). 2022; 9(9):e2105278. PMC: 8948562. DOI: 10.1002/advs.202105278. View

Kim Y, Park S, Kim S . Designing photonic microparticles with droplet microfluidics. Chem Commun (Camb). 2022; 58(74):10303-10328. DOI: 10.1039/d2cc03629k. View

Shao C, Chi J, Shang L, Fan Q, Ye F . Droplet microfluidics-based biomedical microcarriers. Acta Biomater. 2021; 138:21-33. DOI: 10.1016/j.actbio.2021.10.037. View

10.

Cheng O, Qiao T, Sheldon M, Son D . Size- and temperature-dependent photoluminescence spectra of strongly confined CsPbBr quantum dots. Nanoscale. 2020; 12(24):13113-13118. DOI: 10.1039/d0nr02711a. View

11.

Cai Q, Castagnola V, Boselli L, Moura A, Lopez H, Zhang W . A microfluidic approach for synthesis and kinetic profiling of branched gold nanostructures. Nanoscale Horiz. 2022; 7(3):288-298. DOI: 10.1039/d1nh00540e. View

12.

Baek J, Shen Y, Lignos I, Bawendi M, Jensen K . Multistage Microfluidic Platform for the Continuous Synthesis of III-V Core/Shell Quantum Dots. Angew Chem Int Ed Engl. 2018; 57(34):10915-10918. DOI: 10.1002/anie.201805264. View

13.

Kaur B, Kumar S, Kaushik B . Recent advancements in optical biosensors for cancer detection. Biosens Bioelectron. 2021; 197:113805. DOI: 10.1016/j.bios.2021.113805. View

14.

Ochoa-Vazquez G, Kharisov B, Arizmendi-Morquecho A, Cario A, Aymonier C, Marre S . Continuous Segmented-Flow Synthesis of Ag and Au Nanoparticles Using a Low Cost Microfluidic PTFE Tubing Reactor. IEEE Trans Nanobioscience. 2021; 21(1):135-140. DOI: 10.1109/TNB.2021.3101189. View

15.

Wei M, Darcie T, Xu W, Gao Y, Mundel H, Stewart Aitchison J . Enhancing the Sensitivity of Surface Plasmon Resonance Measurements Utilizing Polymer Film/Au Assemblies. Anal Chem. 2021; 93(49):16718-16726. DOI: 10.1021/acs.analchem.1c04546. View

16.

Jeong Y, Kook Y, Lee K, Koh W . Metal enhanced fluorescence (MEF) for biosensors: General approaches and a review of recent developments. Biosens Bioelectron. 2018; 111:102-116. DOI: 10.1016/j.bios.2018.04.007. View

17.

Haleem A, Javaid M, Singh R, Suman R . Telemedicine for healthcare: Capabilities, features, barriers, and applications. Sens Int. 2021; 2:100117. PMC: 8590973. DOI: 10.1016/j.sintl.2021.100117. View

18.

Ma W, Liu D, Ling S, Zhang J, Chen Z, Lu Y . High-Throughput and Controllable Fabrication of Helical Microfibers by Hydrodynamically Focusing Flow. ACS Appl Mater Interfaces. 2021; 13(49):59392-59399. DOI: 10.1021/acsami.1c20720. View

19.

Shestopalov I, Tice J, Ismagilov R . Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system. Lab Chip. 2004; 4(4):316-21. DOI: 10.1039/b403378g. View

20.

Bah M, Bilal H, Wang J . Fabrication and application of complex microcapsules: a review. Soft Matter. 2019; 16(3):570-590. DOI: 10.1039/c9sm01634a. View