Kidney Transplant Recipient with History of HIV, HBV, and Past HCV Infection

Overview

Journal AIDS Res Ther

Publisher Biomed Central

Specialty Infectious Diseases

Date 2024 Aug 26

PMID 39187870

Authors

Jose Ignacio Cerrillos-Gutierrez

Ricardo Parra-Guerra

Alfredo Gutierrez-Govea

Jorge Andrade-Sierra

Eduardo Gonzalez-Espinoza

Daniel Nuno-Diaz

Martha Jessica Herrera-Rodriguez

Maribel Avila-Moran

Ana Luisa Corona-Nakamura

Luz Yasmin Hinogiante-Segura

Claudia Alejandra Mendoza-Cerpa

Affiliations

Soon will be listed here.

Abstract

Chronic viral infections caused by the human immunodeficiency virus (HIV), hepatitis C (HCV), and hepatitis B (HBV) are common among patients with end-stage renal disease (ESKD). These infections were once considered contraindications to kidney transplantation due to potential risks associated with long-term immunosuppression. Improved management and antiviral therapies have changed the prognosis and survival of this group of patients, along with an increased experience in transplanting people with these viral infections. We report the first successful kidney transplant in an ESKD patient on hemodialysis with a history of concomitant HIV, HCV and HBV infection in Mexico.

References

Thongprayoon C, Kaewput W, Sharma K, Wijarnpreecha K, Leeaphorn N, Ungprasert P . Outcomes of kidney transplantation in patients with hepatitis B virus infection: A systematic review and meta-analysis. World J Hepatol. 2018; 10(2):337-346. PMC: 5838452. DOI: 10.4254/wjh.v10.i2.337. View

Rollins B, Farouk S, DeBoccardo G, Lerner S, Rana M, Huprikar S . Higher rates of rejection in HIV-infected kidney transplant recipients on ritonavir-boosted protease inhibitors: 3-year follow-up study. Clin Transplant. 2019; 33(6):e13534. DOI: 10.1111/ctr.13534. View

Stock P, Barin B, Murphy B, Hanto D, Diego J, Light J . Outcomes of kidney transplantation in HIV-infected recipients. N Engl J Med. 2010; 363(21):2004-14. PMC: 3028983. DOI: 10.1056/NEJMoa1001197. View

Cohen J, Locke J, Shelton B, Reed R, Mustian M, MacLennan P . Disparity in access to kidney allograft offers among transplant candidates with human immunodeficiency virus. Clin Transplant. 2018; 33(2):e13466. PMC: 6386602. DOI: 10.1111/ctr.13466. View

Sawinski D, Wyatt C, Casagrande L, Myoung P, Bijan I, Akalin E . Factors associated with failure to list HIV-positive kidney transplant candidates. Am J Transplant. 2009; 9(6):1467-71. PMC: 2742975. DOI: 10.1111/j.1600-6143.2009.02637.x. View

Te H, Doucette K . Viral hepatitis: Guidelines by the American Society of Transplantation Infectious Disease Community of Practice. Clin Transplant. 2019; 33(9):e13514. DOI: 10.1111/ctr.13514. View

Sawinski D, Wong T, Goral S . Current state of kidney transplantation in patients with HIV, hepatitis C, and hepatitis B infection. Clin Transplant. 2020; 34(10):e14048. DOI: 10.1111/ctr.14048. View

Sawinski D, Shelton B, Mehta S, Reed R, MacLennan P, Gustafson S . Impact of Protease Inhibitor-Based Anti-Retroviral Therapy on Outcomes for HIV+ Kidney Transplant Recipients. Am J Transplant. 2017; 17(12):3114-3122. DOI: 10.1111/ajt.14419. View

Sawinski D, Forde K, Eddinger K, Troxel A, Blumberg E, Tebas P . Superior outcomes in HIV-positive kidney transplant patients compared with HCV-infected or HIV/HCV-coinfected recipients. Kidney Int. 2015; 88(2):341-9. PMC: 5113138. DOI: 10.1038/ki.2015.74. View

10.

Baid S, Cosimi A, Tolkoff-Rubin N, Colvin R, Williams W, Pascual M . Renal disease associated with hepatitis C infection after kidney and liver transplantation. Transplantation. 2000; 70(2):255-61. DOI: 10.1097/00007890-200007270-00001. View

11.

Sawinski D, Forde K, Lo Re 3rd V, Goldberg D, Cohen J, Locke J . Mortality and Kidney Transplantation Outcomes Among Hepatitis C Virus-Seropositive Maintenance Dialysis Patients: A Retrospective Cohort Study. Am J Kidney Dis. 2019; 73(6):815-826. PMC: 6535135. DOI: 10.1053/j.ajkd.2018.11.009. View

12.

Fabrizi F, Martin P, Dixit V, Bunnapradist S, Kanwal F, Dulai G . Post-transplant diabetes mellitus and HCV seropositive status after renal transplantation: meta-analysis of clinical studies. Am J Transplant. 2005; 5(10):2433-40. DOI: 10.1111/j.1600-6143.2005.01040.x. View

13.

Yap D, Tang C, Yung S, Choy B, Yuen M, Chan T . Long-term outcome of renal transplant recipients with chronic hepatitis B infection-impact of antiviral treatments. Transplantation. 2010; 90(3):325-30. DOI: 10.1097/TP.0b013e3181e5b811. View

14.

Luan F, Schaubel D, Zhang H, Jia X, Pelletier S, Port F . Impact of immunosuppressive regimen on survival of kidney transplant recipients with hepatitis C. Transplantation. 2008; 85(11):1601-6. DOI: 10.1097/TP.0b013e3181722f3a. View

15.

Roth D, Gaynor J, Reddy K, Ciancio G, Sageshima J, Kupin W . Effect of kidney transplantation on outcomes among patients with hepatitis C. J Am Soc Nephrol. 2011; 22(6):1152-60. PMC: 3103735. DOI: 10.1681/ASN.2010060668. View

16.

Van Maarseveen E, Rogers C, Trofe-Clark J, van Zuilen A, Mudrikova T . Drug-drug interactions between antiretroviral and immunosuppressive agents in HIV-infected patients after solid organ transplantation: a review. AIDS Patient Care STDS. 2012; 26(10):568-81. DOI: 10.1089/apc.2012.0169. View