Life's Essential 8 and Risk of Subclinical Atherosclerosis Progression: a Prospective Cohort Study

Overview

Journal J Geriatr Cardiol

Specialty Geriatrics

Date 2024 Aug 26

PMID 39183952

Authors

Shi-Yu Zhou

Fang-Chao Liu

Shu-Feng Chen

Jian-Xin Li

Jie Cao

Ke-Yong Huang

Zheng-Hao Tang

Feng-Chao Liang

Dong-Sheng Hu

Lian-Cheng Zhao

Ying Li

Jian-Feng Huang

Xiang-Feng Lu

Bin Lu

Dong-Feng Gu

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have demonstrated the benefits of ideal cardiovascular health (CVH) in reducing cardiovascular risk. However, its role in subclinical atherosclerosis (SA) progression remains unclear. We aim to examine the association of CVH, estimated by the American Heart Association's new Life's Essential 8 (LE8), with the progression of SA.

Methods: This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for 5.7 years. The LE8 score (range, 0-100) consisted of blood pressure, lipids, glucose, body mass index, smoking status, diet health, physical activity and sleep health was evaluated in 1998 and 2008-2009. Progression of SA was determined by carotid plaque and coronary artery calcification (CAC) in 2008-2009 and 2013-2014. Log-binomial regression model was used to estimate the association of LE8 score with SA progression.

Results: Each 10 points increment in LE8 score was associated with 15.2% (RR: 0.848, 95% CI: 0.797-0.902), 17.7% (RR: 0.823, 95% CI: 0.766-0.884) and 12.0% (RR: 0.880, 95% CI: 0.845-0.916) lower risks of carotid plaque, CAC and overall SA progression, respectively. Compared with participants with non-ideal CVH at both visits, the participants with ideal CVH at both visits had 39.1% (RR: 0.609, 95% CI: 0.494-0.752), 41.0% (RR: 0.590, 95% CI: 0.456-0.764) and 29.7% (RR: 0.703, 95% CI: 0.598-0.825) lower risks of carotid plaque, CAC and overall SA progression, respectively.

Conclusions: Higher LE8 scores were associated with lower risks of SA progression. Besides, long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

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