Glucocorticoid Use and Parenteral Nutrition Are Risk Factors for Catheter-related Bloodstream Infection: a Retrospective Study

Overview

Journal Asian Biomed (Res Rev News)

Date 2024 Aug 23

PMID 39175949

Authors

Lipeng Huang

Shanshan Li

Ronglin Jiang

Shu Lei

Jiannong Wu

Liquan Huang

Meifei Zhu

Affiliations

Soon will be listed here.

Abstract

Background: Catheter-related candidemia (CRC) is a serious catheter-related bloodstream infection (CRBSI) caused by spp., with higher mortality than CRBSIs caused by other organisms.

Objective: To identify the risk factors for CRBSI. The clinical characteristics of 297 patients with CRBSI in a local hospital from January 2007 to June 2015 were collected, including 33 CRBSI and 264 non- CRBSI.

Method: The associations of CRBSI with the clinical variables were examined using univariate and multivariate analyses.

Results: Multivariate analysis showed that glucocorticoid use (odds ratio [OR] = 10.313, 95% confidence interval [CI] = 2.032-52.330, = 0.005) and parenteral nutrition (OR = 5.400, 95% CI = 0.472-61.752, = 0.0175) were independent risk factors for CRBSI. The most prevalent species were (42.4%) and (36.36%). Of the 33 CRBSI cases, 31 (93.93%) had indwelling central venous catheters (CVC) for ≥14 d. The mortality of CRBSI was remarkably higher than that of bacteria CRBSI. Patients with timely catheter removal and appropriate antifungal treatment had dramatically increased 28-d survival compared with those with untimely catheter removal + inappropriate antifungal treatment (88.89% vs. 0, = 0.006).

Conclusion: The study identified glucocorticoid use and parenteral nutrition as independent risk factors for CRBSI. The outcome of candidemia was associated with the duration of CVC indwelling and antifungal treatment.

Citing Articles

Control of parenteral blood stream infections in patients who need parenteral nutrition.

Asian Biomed (Res Rev News). 2024; 18(3):90-91.

PMID: 39175953 PMC: 11338269. DOI: 10.2478/abm-2024-0014.

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