» Articles » PMID: 39174015

Platelet and Erythrocyte Membranes Coassembled Biomimetic Nanoparticles for Heart Failure Treatment

Overview
Journal ACS Nano
Specialty Biotechnology
Date 2024 Aug 22
PMID 39174015
Authors
Affiliations
Soon will be listed here.
Abstract

Cardiac fibrosis is a prevalent pathological process observed in the progression of numerous cardiovascular diseases and is associated with an increased risk of sudden cardiac death. Although the BRD4 inhibitor JQ1 has powerful antifibrosis properties, its clinical application is extremely limited due to its side effects. There remains an unmet need for effective, safe, and low-cost treatments. Here, we present a multifunctional biomimetic nanoparticle drug delivery system (PM&EM nanoparticles) assembled by platelet membranes and erythrocyte membranes for targeted JQ1 delivery in treating cardiac fibrosis. The platelet membrane endows PM&EM nanoparticles with the ability to target cardiac myofibroblasts and collagen, while the participation of the erythrocyte membrane enhances the long-term circulation ability of the formulated nanoparticles. In addition, PM&EM nanoparticles can deliver sufficient JQ1 with controllable release, achieving excellent antifibrosis effects. Based on these advantages, it is demonstrated in both pressures overloaded induced mouse cardiac fibrosis model and MI-induced mouse cardiac fibrosis that injection of the fusion membrane biomimetic nanodrug carrier system effectively reduced fibroblast activation, collagen secretion, and improved cardiac fibrosis. Moreover, it significantly mitigated the toxic and side effects of long-term JQ1 treatment on the liver, kidney, and intestinal tract. Mechanically, bioinformatics prediction and experimental validation revealed that PM&EM/JQ1 NPs reduced liver and kidney damage via alleviated oxidative stress and mitigated cardiac fibrosis via the activation of oxidative phosphorylation activation. These results highlight the potential value of integrating native platelet and erythrocyte membranes as a multifunctional biomimetic drug delivery system for treating cardiac fibrosis and preventing drug side effects.

Citing Articles

Advanced Nanomedicine Delivery Systems for Cardiovascular Diseases: Viral and Non-Viral Strategies in Targeted Therapy.

Chen Q, Yu T, Gong J, Shan H Molecules. 2025; 30(4).

PMID: 40005272 PMC: 11858567. DOI: 10.3390/molecules30040962.

References
1.
Jou S, Mendez S, Feinman J, Mitrani L, Fuster V, Mangiola M . Heart transplantation: advances in expanding the donor pool and xenotransplantation. Nat Rev Cardiol. 2023; 21(1):25-36. DOI: 10.1038/s41569-023-00902-1. View

2.
Li Y, Che J, Chang L, Guo M, Bao X, Mu D . CD47- and Integrin α4/β1-Comodified-Macrophage-Membrane-Coated Nanoparticles Enable Delivery of Colchicine to Atherosclerotic Plaque. Adv Healthc Mater. 2021; 11(4):e2101788. DOI: 10.1002/adhm.202101788. View

3.
Dai J, Wu M, Wang Q, Ding S, Dong X, Xue L . Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy. Natl Sci Rev. 2021; 8(6):nwab039. PMC: 8288176. DOI: 10.1093/nsr/nwab039. View

4.
Cui J, Wang M, Zhang W, Sun J, Zhang Y, Zhao L . Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton's jelly-derived mesenchymal stem cells: a novel therapeutic approach. Diabetol Metab Syndr. 2024; 16(1):84. PMC: 11020616. DOI: 10.1186/s13098-024-01332-w. View

5.
Li Y, Wang Y, Xia Z, Xie Y, Ke D, Song B . Noninvasive platelet membrane-coated FeO nanoparticles identify vulnerable atherosclerotic plaques. Smart Med. 2024; 3(2):e20240006. PMC: 11235982. DOI: 10.1002/SMMD.20240006. View