Interplay of Mitochondrial Calcium Signalling and Reactive Oxygen Species Production in the Brain

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2024 Aug 22

PMID 39171662

Authors

Plamena R Angelova

Andrey Y Abramov

Affiliations

Soon will be listed here.

Abstract

Intracellular communication and regulation in brain cells is controlled by the ubiquitous Ca2+ and by redox signalling. Both of these independent signalling systems regulate most of the processes in cells including the cell surviving mechanism or cell death. In physiology Ca2+ can regulate and trigger reactive oxygen species (ROS) production by various enzymes and in mitochondria but ROS could also transmit redox signal to calcium levels via modification of calcium channels or phospholipase activity. Changes in calcium or redox signalling could lead to severe pathology resulting in excitotoxicity or oxidative stress. Interaction of the calcium and ROS is essential to trigger opening of mitochondrial permeability transition pore - the initial step of apoptosis, Ca2+ and ROS-induced oxidative stress involved in necrosis and ferroptosis. Here we review the role of redox signalling and Ca2+ in cytosol and mitochondria in the physiology of brain cells - neurons and astrocytes and how this integration can lead to pathology, including ischaemia injury and neurodegeneration.

Citing Articles

Point of No Return-What Is the Threshold of Mitochondria With Permeability Transition in Cells to Trigger Cell Death.

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PMID: 39760157 PMC: 11701880. DOI: 10.1002/jcp.31521.

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