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Racial Disparities in Pulse Oximetry, in COVID-19 and ICU Settings

Overview
Journal Crit Care Explor
Specialty Critical Care
Date 2024 Aug 22
PMID 39170877
Authors
Carmen A T Reep
Lucas M Fleuren
Leo Heunks
Evert-Jan Wils
Affiliations
Soon will be listed here.
Abstract

Objectives Background: This study aimed to assess the impact of race on pulse oximetry reliability, taking into account Spo ranges, COVID-19 diagnosis, and ICU admission.

Design: Retrospective cohort study covering admissions from January 2020 to April 2024.

Setting: National COVID Cohort Collaborative (N3C) database, consisting of electronic health records from 80 U.S. institutions.

Patients/subjects: Patients were selected from the N3C database based on the availability of data on self-identified race and both pulse oximetry estimated Spo and Sao. Subgroups included patients in ICU and non-ICU settings, with or without a diagnosis of COVID-19 disease.

Interventions: None.

Measurements And Main Results: The agreement between Spo and Sao was assessed across racial groups (American Indian or Alaska Native, Asian, Black, Hispanic or Latino, Pacific Islander, and White). Each patient's initial Sao measurement was matched with the closest Spo values recorded within the preceding 10-minute time frame. The risk of hidden hypoxemia (Spo ≥ 88% but Sao < 88%) was determined for various Spo ranges, races, and clinical scenarios. We used a generalized logistic mixed-effects model to evaluate the impact of relevant variables, such as COVID-19, ICU admission, age, sex, race, and Spo, on the risk of hidden hypoxemia, while accounting for the random effects within each hospital. A total of 80,541 patients were included, consisting of 596 American Indian or Alaska Native, 2,729 Asian, 11,889 Black, 13,154 Hispanic or Latino, 221 Pacific Islander, and 51,952 White individuals. Discrepancies between Spo and Sao were observed across all racial groups, with the most pronounced bias in Black patients. Hidden hypoxemia rates were higher in Black patients across all Spo subgroups, for all clinical scenarios. The odds of hidden hypoxemia were higher for Black and Hispanic or Latino patients and for those with COVID-19 disease.

Conclusions: Race significantly impacts pulse oximetry reliability. Not only Black and Hispanic or Latino patients were at higher risk for hidden hypoxemia, but also those admitted with a COVID-19 diagnosis. Future in-depth explorations into the underlying causes and potential solutions are needed.

References
1.
Crooks C, West J, Morling J, Simmonds M, Juurlink I, Briggs S . Pulse oximeter measurements vary across ethnic groups: an observational study in patients with COVID-19. Eur Respir J. 2022; 59(4). PMC: 8796692. DOI: 10.1183/13993003.03246-2021. View
2.
Fox T, Mazalewski W, Tran H, Lindsey T, Krishnan A, Kantrow S . Discordance Between Invasive and NonInvasive Oxygen Saturation in Critically Ill COVID-19 Patients. J Intensive Care Med. 2023; 38(12):1151-1157. PMC: 10331117. DOI: 10.1177/08850666231186947. View
3.
Haendel M, Chute C, Bennett T, Eichmann D, Guinney J, Kibbe W . The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment. J Am Med Inform Assoc. 2020; 28(3):427-443. PMC: 7454687. DOI: 10.1093/jamia/ocaa196. View
4.
Wong A, Charpignon M, Kim H, Josef C, de Hond A, Fojas J . Analysis of Discrepancies Between Pulse Oximetry and Arterial Oxygen Saturation Measurements by Race and Ethnicity and Association With Organ Dysfunction and Mortality. JAMA Netw Open. 2021; 4(11):e2131674. PMC: 9178439. DOI: 10.1001/jamanetworkopen.2021.31674. View
5.
Valbuena V, Seelye S, Sjoding M, Valley T, Dickson R, Gay S . Racial bias and reproducibility in pulse oximetry among medical and surgical inpatients in general care in the Veterans Health Administration 2013-19: multicenter, retrospective cohort study. BMJ. 2022; 378:e069775. PMC: 9254870. DOI: 10.1136/bmj-2021-069775. View