Effects of Glucocorticoid Replacement Therapy in Patients with Pituitary Disease: A New Perspective for Personalized Replacement Therapy

Overview

Journal Rev Endocr Metab Disord

Publisher Springer

Specialty Endocrinology

Date 2024 Aug 21

PMID 39168952

Authors

Sabrina Chiloiro

Alessandra Vicari

Ginevra Mongelli

Flavia Costanza

Antonella Giampietro

Pier Paolo Mattogno

Liverana Lauretti

Alessandro Olivi

Laura De Marinis

Francesco Doglietto

Antonio Bianchi

Alfredo Pontecorvi

Affiliations

Soon will be listed here.

Abstract

Secondary adrenal insufficiency (SAI) is an endocrine disorder due to impaired secretion of ACTH resulting from any disease affecting the pituitary gland. Glucocorticoid replacement therapy is mandatory to ensure patient survival, haemodynamic stability, and quality of life. In fact, a correct dose adjustement is mandatory due to the fact that inappropriately low doses expose patients to hypoadrenal crisis, while inappropriately high doses contribute to glucose metabolic and cardiovascular deterioration. This review analyses the current evidence from available publications on the epidemiology and aetiology of SAI and examines the association between glucocorticoid replacement therapy and glucometabolic and cardiovascular effects.

Citing Articles

Cancer screening in patients with acromegaly: a plea for a personalized approach and international registries.

Demarchis L, Chiloiro S, Giampietro A, De Marinis L, Bianchi A, Fleseriu M Rev Endocr Metab Disord. 2025; .

PMID: 40088375 DOI: 10.1007/s11154-025-09957-6.

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