Targeting Autophagy: A Promising Therapeutic Strategy for Diabetes Mellitus and Diabetic Nephropathy

Overview

Journal Diabetes Ther

Specialty Cardiology & Vascular Diseases

Date 2024 Aug 21

PMID 39167303

Authors

Qi-Rui Li

Hui-Ying Xu

Rui-Ting Ma

Yuan-Yuan Ma

Mei-Juan Chen

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus (DM) significantly impairs patients' quality of life, primarily because of its complications, which are the leading cause of mortality among individuals with the disease. Autophagy has emerged as a key process closely associated with DM, including its complications such as diabetic nephropathy (DN). DN is a major complication of DM, contributing significantly to chronic kidney disease and renal failure. The intricate connection between autophagy and DM, including DN, highlights the potential for new therapeutic targets. This review examines the interplay between autophagy and these conditions, aiming to uncover novel approaches to treatment and enhance our understanding of their underlying pathophysiology. It also explores the role of autophagy in maintaining renal homeostasis and its involvement in the development and progression of DM and DN. Furthermore, the review discusses natural compounds that may alleviate these conditions by modulating autophagy.

Citing Articles

Autophagy and Mitophagy in Diabetic Kidney Disease-A Literature Review.

Stanigut A, Tuta L, Pana C, Alexandrescu L, Suceveanu A, Blebea N Int J Mol Sci. 2025; 26(2).

PMID: 39859520 PMC: 11766107. DOI: 10.3390/ijms26020806.

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