Duration Mismatch Negativity Under Varying Deviant Conditions in Individuals with High Schizotypal Traits

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2024 Aug 21

PMID 39165502

Authors

Jue Deng

Yuanjun Zhang

Liqin Lu

Yuanhua Ou

Xianghui Lai

Siwei Chen

Yiduo Ye

Affiliations

Soon will be listed here.

Abstract

Background: Although impaired auditory mismatch negativity (MMN) has consistently been found in individuals with schizophrenia, there are few and inconsistent reports on nonclinical individuals with schizotypy. To date, no studies have thoroughly assessed MMN with different degrees of deviant oddballs in nonclinical schizotypal samples. The aim of this study was to examine the extent of duration MMN (dMMN) amplitudes under two deviant duration conditions (large and small) in nonclinical participants with high schizotypal traits.

Methods: An extreme-group design was utilized, in which 63 participants from the schizotypy and control groups were selected from a pool of 1519 young adults using the Schizotypal Personality Questionnaire (SPQ). MMN was measured using passive duration oddball paradigms. Basic demographic information and musical backgrounds were assessed and matched, while depression and anxiety were evaluated and controlled for. The repeated measures analysis of covariance was utilized to evaluate differences in dMMN between groups. The Bonferroni correction was applied for multiple comparisons. Partial correlation and multiple linear regression analyses were conducted to investigate the association between dMMN amplitudes and SPQ scores.

Results: The amplitudes of dMMN at Cz were significantly increased under the large deviance condition in nonclinical schizotypal individuals ( = 4.36, = .04). Large-deviance dMMN amplitudes at Fz were positively correlated with mild cognitive-perceptual symptoms in the control group ( = .42, = .03). However, as schizophrenia-like symptoms worsened and approached the clinical threshold for schizophrenia, small-deviance dMMN amplitudes at Cz showed negative associations with the cognitive-perceptual factor in the schizotypy group ( = -.40, = .04).

Conclusion: These results suggest the importance of considering the degree of deviation in duration when implementing the auditory oddball paradigm among nonclinical participants with schizotypal traits. In addition, our findings reveal a potential non-linear relationship between bottom-up auditory processing and the positive dimension of the schizophrenia spectrum.

References

Belger A, Yucel G, Donkers F . In search of psychosis biomarkers in high-risk populations: is the mismatch negativity the one we've been waiting for?. Biol Psychiatry. 2011; 71(2):94-5. DOI: 10.1016/j.biopsych.2011.11.009. View

Abraham A . Is there an inverted-U relationship between creativity and psychopathology?. Front Psychol. 2014; 5:750. PMC: 4112907. DOI: 10.3389/fpsyg.2014.00750. View

Haigh S, Coffman B, Salisbury D . Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis. Clin EEG Neurosci. 2016; 48(1):3-10. PMC: 5768309. DOI: 10.1177/1550059416645980. View

Bonetti L, Haumann N, Vuust P, Kliuchko M, Brattico E . Risk of depression enhances auditory Pitch discrimination in the brain as indexed by the mismatch negativity. Clin Neurophysiol. 2017; 128(10):1923-1936. DOI: 10.1016/j.clinph.2017.07.004. View

Qin X, Liu J, Cui J, Shi H, Ye J, Yang T . Prospective memory performance and its improvement in individuals with high schizotypal traits: Evidence from eye-tracking studies. Clin Neurophysiol. 2022; 143:133-142. DOI: 10.1016/j.clinph.2022.09.004. View

Raine A . The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull. 1991; 17(4):555-64. DOI: 10.1093/schbul/17.4.555. View

Liu Y, Shen X, Zhu Y, Xu Y, Cai W, Shen M . Mismatch negativity in paranoid, schizotypal, and antisocial personality disorders. Neurophysiol Clin. 2007; 37(2):89-96. DOI: 10.1016/j.neucli.2007.03.001. View

Javitt D, Sweet R . Auditory dysfunction in schizophrenia: integrating clinical and basic features. Nat Rev Neurosci. 2015; 16(9):535-50. PMC: 4692466. DOI: 10.1038/nrn4002. View

Beck A, Beamesderfer A . Assessment of depression: the depression inventory. Mod Probl Pharmacopsychiatry. 1974; 7(0):151-69. DOI: 10.1159/000395074. View

10.

Naatanen R, Petersen B, Torppa R, Lonka E, Vuust P . The MMN as a viable and objective marker of auditory development in CI users. Hear Res. 2017; 353:57-75. DOI: 10.1016/j.heares.2017.07.007. View

11.

van Os J, Reininghaus U . Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry. 2016; 15(2):118-24. PMC: 4911787. DOI: 10.1002/wps.20310. View

12.

Fujioka M, Kirihara K, Koshiyama D, Tada M, Nagai T, Usui K . Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis. Front Psychiatry. 2020; 11:770. PMC: 7416637. DOI: 10.3389/fpsyt.2020.00770. View

13.

Donaldson K, Novak K, Foti D, Marder M, Perlman G, Kotov R . Associations of mismatch negativity with psychotic symptoms and functioning transdiagnostically across psychotic disorders. J Abnorm Psychol. 2020; 129(6):570-580. PMC: 9236595. DOI: 10.1037/abn0000506. View

14.

Coffman B, Haigh S, Murphy T, Salisbury D . Impairment in Mismatch Negativity but not Repetition Suppression in Schizophrenia. Brain Topogr. 2017; 30(4):521-530. PMC: 5533081. DOI: 10.1007/s10548-017-0571-1. View

15.

Ettinger U, Meyhofer I, Steffens M, Wagner M, Koutsouleris N . Genetics, cognition, and neurobiology of schizotypal personality: a review of the overlap with schizophrenia. Front Psychiatry. 2014; 5:18. PMC: 3931123. DOI: 10.3389/fpsyt.2014.00018. View

16.

Ettinger U, Mohr C, Gooding D, Cohen A, Rapp A, Haenschel C . Cognition and brain function in schizotypy: a selective review. Schizophr Bull. 2015; 41 Suppl 2:S417-26. PMC: 4373634. DOI: 10.1093/schbul/sbu190. View

17.

Gross M, Araujo D, Zedelius C, Schooler J . Is perception the missing link between creativity, curiosity and schizotypy? Evidence from spontaneous eye-movements and responses to auditory oddball stimuli. Neuroimage. 2019; 202:116125. DOI: 10.1016/j.neuroimage.2019.116125. View

18.

Fonseca Pedrero E, Debbane M . Schizotypal traits and psychotic-like experiences during adolescence: An update. Psicothema. 2017; 29(1):5-17. DOI: 10.7334/psicothema2016.209. View

19.

Abe D, Arai M, Itokawa M . Music-evoked emotions in schizophrenia. Schizophr Res. 2016; 185:144-147. DOI: 10.1016/j.schres.2016.12.013. View

20.

Curtis M, Coffman B, Salisbury D . Pitch and Duration Mismatch Negativity are Associated With Distinct Auditory Cortex and Inferior Frontal Cortex Volumes in the First-Episode Schizophrenia Spectrum. Schizophr Bull Open. 2021; 2(1):sgab005. PMC: 7953127. DOI: 10.1093/schizbullopen/sgab005. View