Primary Cardiac Synovial Sarcoma Originating from the Atrial Septum and Associated Pulmonary Infarction: a Case Report

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2024 Aug 20

PMID 39162837

Authors

Nie Xu

Kang Xie

Dong Xin

Zhonglei Liang

Yongjun Zeng

Affiliations

Soon will be listed here.

Abstract

Background: Primary cardiac synovial sarcoma is a rare condition with limited treatment options for advanced stages. Surgery and chemotherapy are currently the mainstay treatments; however, survival rates remain low.

Case Presentation: A 64-year-old woman presenting with symptoms of chest tightness and shortness of breath was found to have an obstructive right atrial mass, along with pulmonary infarction and metastasis. She was ultimately diagnosed with advanced primary cardiac synovial sarcoma. Following surgery, the patient's symptoms improved, and she underwent chemotherapy and anti-angiogenic therapy, but unfortunately, her survival time was only 8 months.

Conclusion: This case report aims to enhance clinicians' understanding of the diagnosis and treatment of primary cardiac synovial sarcoma. Enhancing both survival outcomes and quality of life in individuals with primary cardiac synovial sarcoma continues to present a significant challenge.

References

Kirkham M, Kalivas A, Fatema K, Luelling S, Dubansky B, Dubansky B . Underlying Ossification Phenotype in a Murine Model of Metastatic Synovial Sarcoma. Int J Mol Sci. 2020; 21(7). PMC: 7177647. DOI: 10.3390/ijms21072636. View

Wang J, Li N . Primary cardiac synovial sarcoma. Ann Thorac Surg. 2013; 95(6):2202-9. DOI: 10.1016/j.athoracsur.2013.01.030. View

Sultan I, Bianco V, Habertheuer A, Kilic A, Gleason T, Aranda-Michel E . Long-Term Outcomes of Primary Cardiac Malignancies: Multi-Institutional Results From the National Cancer Database. J Am Coll Cardiol. 2020; 75(18):2338-2347. DOI: 10.1016/j.jacc.2020.03.041. View

Coli A, Cassano A, Novello M, Ranelletti F, Lauriola L . Primary cardiac synovial sarcoma: A review correlating outcomes with surgery and adjuvant therapy. J Card Surg. 2019; 34(11):1321-1327. DOI: 10.1111/jocs.14214. View

Bishop J, Alaggio R, Zhang L, Seethala R, Antonescu C . Adamantinoma-like Ewing family tumors of the head and neck: a pitfall in the differential diagnosis of basaloid and myoepithelial carcinomas. Am J Surg Pathol. 2015; 39(9):1267-74. PMC: 4537687. DOI: 10.1097/PAS.0000000000000460. View

Nowicki T, Akiyama R, Huang R, Shintaku I, Wang X, Tumeh P . Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma. Cancer Immunol Res. 2017; 5(2):118-126. PMC: 5290092. DOI: 10.1158/2326-6066.CIR-16-0148. View

Teng F, Chen D, Li Y, Fang W, Yang S, Shang J . Primary cardiac synovial sarcoma: a clinicopathological, immunohistochemical, and molecular genetics study of five clinical cases. Cardiovasc Pathol. 2020; 50:107286. DOI: 10.1016/j.carpath.2020.107286. View

Hannachi Sassi S, Zargouni N, Saadi Dakhlia M, Mrad K, Cammoun M, Ben Romdhane K . Primary synovial sarcoma of the heart. A clinicopathologic study of one case and review of the literature. Pathologica. 2004; 96(1):29-34. View

Sbaraglia M, Dei Tos A . The pathology of soft tissue sarcomas. Radiol Med. 2018; 124(4):266-281. DOI: 10.1007/s11547-018-0882-7. View

10.

Fisher C, Montgomery E, Healy V . Calponin and h-caldesmon expression in synovial sarcoma; the use of calponin in diagnosis. Histopathology. 2003; 42(6):588-93. DOI: 10.1046/j.1365-2559.2003.01652.x. View

11.

Neubert N, Schmittnaegel M, Bordry N, Nassiri S, Wald N, Martignier C . T cell-induced CSF1 promotes melanoma resistance to PD1 blockade. Sci Transl Med. 2018; 10(436). PMC: 5957531. DOI: 10.1126/scitranslmed.aan3311. View

12.

Lak N, Voormanns T, Zappeij-Kannegieter L, van Zogchel L, Fiocco M, van Noesel M . Improving Risk Stratification for Pediatric Patients with Rhabdomyosarcoma by Molecular Detection of Disseminated Disease. Clin Cancer Res. 2021; 27(20):5576-5585. PMC: 9401561. DOI: 10.1158/1078-0432.CCR-21-1083. View

13.

Marchione D, Ilieva I, Devins K, Sharpe D, Pappin D, Garcia B . HYPERsol: High-Quality Data from Archival FFPE Tissue for Clinical Proteomics. J Proteome Res. 2020; 19(2):973-983. PMC: 7515636. DOI: 10.1021/acs.jproteome.9b00686. View

14.

Jo V, Fletcher C . WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition. Pathology. 2014; 46(2):95-104. DOI: 10.1097/PAT.0000000000000050. View

15.

Nunnery S, Bottinor W, Das S . Cardiac Masses in a Patient With Pancreatic Adenocarcinoma and a History of Breast Carcinoma. JAMA Oncol. 2020; 6(6):917-918. PMC: 8127980. DOI: 10.1001/jamaoncol.2020.0086. View

16.

Su B, Hung G, Tu Y, Yeh W, Lin M, Chen J . Marine Antimicrobial Peptide TP4 Exerts Anticancer Effects on Human Synovial Sarcoma Cells via Calcium Overload, Reactive Oxygen Species Production and Mitochondrial Hyperpolarization. Mar Drugs. 2021; 19(2). PMC: 7915578. DOI: 10.3390/md19020093. View