Exploring the Therapeutic Potential of Diterpenes in Gastric Cancer: Mechanisms, Efficacy, and Clinical Prospects

Overview

Journal Biomol Biomed

Specialties Biochemistry
General Medicine

Date 2024 Aug 16

PMID 39151097

Authors

Chenhui Ma

Lei Gao

Kewei Song

Baohong Gu

Bofang Wang

Weigao Pu

Hao Chen

Affiliations

Soon will be listed here.

Abstract

Gastric cancer (GC) remains a significant global health challenge, particularly prevalent in East Asia. Despite advancements in various treatment modalities, the prognosis for patients, especially those in advanced stages, remains poor, highlighting the need for innovative therapeutic approaches. This review explores the promising potential of diterpenes, naturally occurring compounds with robust anticancer properties, derived from diverse sources such as plants, marine organisms, and fungi. Diterpenes have shown the ability to influence reactive oxygen species (ROS) generation, ferroptosis, and autophagy, positioning them as attractive candidates for novel cancer therapies. This review explores the mechanisms of action of diterpenes and their clinical implications for the treatment of GC. Additionally, it addresses the challenges in translating these compounds from preclinical studies to clinical applications, emphasizing the need for further research to enhance their therapeutic profiles and minimize potential side effects. The discussion underscores the importance of diterpenes in future anticancer strategies, particularly in the fight against gastric cancer.

Citing Articles

Plant-derived terpenoids modulating cancer cell metabolism and cross-linked signaling pathways: an updated reviews.

Pandey P, Verma M, Sanghvi G, R R, Joshi K, V K Naunyn Schmiedebergs Arch Pharmacol. 2025; .

PMID: 40019530 DOI: 10.1007/s00210-025-03937-y.

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