Effect of Sp. Infection on Hematological Parameters and Trace Element Status in Children with Iron-deficiency Anemia

Overview

Journal J Parasit Dis

Specialty Parasitology

Date 2024 Aug 15

PMID 39145364

Authors

Doaa A Hamdy

Sameh S Fahmey

Wegdan M Abd El Wahab

Sarah S Mohamed

Yasmen A Mohamed

Affiliations

Soon will be listed here.

Abstract

Iron deficiency anemia (IDA), which causes greater morbidity and mortality in children, has multifactorial causes, including many helminthic and protozoal infections. Herein, the study aimed to find out the frequency and associated risk of sp. infection among children with IDA, together with the estimation of the serum levels of iron, zinc, copper, and vitamin A. Both stool and blood samples were obtained from 90 children with a confirmed diagnosis of IDA and 90 non-anemic children. sp. was diagnosed by direct stool examination and Invitro cultivation methods. Different hematological parameters were recorded, and the serum level of iron, zinc, copper, and vitamin A was measured in serum samples. The overall predominance of in children was 36.7%, significantly higher ( < 0.001) in children with IDA (55.6%) compared to non-anemic controls (17.8%). Furthermore, infected children were 5.781 times more prone to be anemic (OR = 5.781). All IDA cases with positive infection had a mean hemoglobin level of 9.55 g/dl (moderate anemia). While in other non-infected IDA cases, it was 9.56 g/dl, showing no statistical difference ( = 0.845). Serum levels of zinc, iron, and vitamin A considerably decreased, whereas serum copper levels significantly increased in IDA children infected with . The current research is the first in Egypt to indicate that infection in children is a high-risk factor for developing IDA. infection significantly alters the metabolic and biochemical processes and interferes with the absorption of micronutrients and vitamin A in IDA children.

References

Wolonciej M, Milewska E, Roszkowska-Jakimiec W . Trace elements as an activator of antioxidant enzymes. Postepy Hig Med Dosw (Online). 2017; 70(0):1483-1498. DOI: 10.5604/17322693.1229074. View

Kolkhir P, Balakirski G, Merk H, Olisova O, Maurer M . Chronic spontaneous urticaria and internal parasites--a systematic review. Allergy. 2015; 71(3):308-22. DOI: 10.1111/all.12818. View

ElWakil H, Hewedi I . Pathogenic potential of Blastocystis hominis in laboratory mice. Parasitol Res. 2010; 107(3):685-9. DOI: 10.1007/s00436-010-1922-y. View

Zuckerman M, Watts M, Ho H, Meriano F . Blastocystis hominis infection and intestinal injury. Am J Med Sci. 1994; 308(2):96-101. DOI: 10.1097/00000441-199408000-00006. View

El-Badry A, Abd El Wahab W, Hamdy D, Aboud A . Blastocystis subtypes isolated from irritable bowel syndrome patients and co-infection with Helicobacter pylori. Parasitol Res. 2017; 117(1):127-137. DOI: 10.1007/s00436-017-5679-4. View

Olivares J, Fernandez R, Fleta J, Rodriguez G, Clavel A . Serum mineral levels in children with intestinal parasitic infection. Dig Dis. 2003; 21(3):258-61. DOI: 10.1159/000073344. View

Pullan R, Brooker S . The global limits and population at risk of soil-transmitted helminth infections in 2010. Parasit Vectors. 2012; 5:81. PMC: 3419672. DOI: 10.1186/1756-3305-5-81. View

Shi H, Scott M, Stevenson M, Koski K . Energy restriction and zinc deficiency impair the functions of murine T cells and antigen-presenting cells during gastrointestinal nematode infection. J Nutr. 1998; 128(1):20-7. DOI: 10.1093/jn/128.1.20. View

Ertan P, Yereli K, Kurt O, Balcioglu I, Onag A . Serological levels of zinc, copper and iron elements among Giardia lamblia infected children in Turkey. Pediatr Int. 2002; 44(3):286-8. DOI: 10.1046/j.1442-200x.2002.01550.x. View

10.

Scanlan P, Stensvold C, Rajilic-Stojanovic M, Heilig H, de Vos W, OToole P . The microbial eukaryote Blastocystis is a prevalent and diverse member of the healthy human gut microbiota. FEMS Microbiol Ecol. 2014; 90(1):326-30. DOI: 10.1111/1574-6941.12396. View

11.

Stensvold C, Tan K, Clark C . Blastocystis. Trends Parasitol. 2020; 36(3):315-316. DOI: 10.1016/j.pt.2019.12.008. View

12.

Stensvold C, van der Giezen M . Associations between Gut Microbiota and Common Luminal Intestinal Parasites. Trends Parasitol. 2018; 34(5):369-377. DOI: 10.1016/j.pt.2018.02.004. View

13.

Leder K, Hellard M, Sinclair M, Fairley C, Wolfe R . No correlation between clinical symptoms and Blastocystis hominis in immunocompetent individuals. J Gastroenterol Hepatol. 2005; 20(9):1390-4. DOI: 10.1111/j.1440-1746.2005.03868.x. View

14.

Yones D, Galal L, Abdallah A, Zaghlol K . Effect of enteric parasitic infection on serum trace elements and nutritional status in upper Egyptian children. Trop Parasitol. 2015; 5(1):29-35. PMC: 4326990. DOI: 10.4103/2229-5070.145581. View

15.

Zuckerman M, Ho H, Hooper L, Anderson B, Polly S . Frequency of recovery of Blastocystis hominis in clinical practice. J Clin Gastroenterol. 1990; 12(5):525-32. DOI: 10.1097/00004836-199010000-00008. View

16.

Zhang H, Li W, Yan Q, He L, Su Y . [Impact of blastocystis hominis infection on ultrastructure of intestinal mucosa in mice]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006; 24(3):187-91. View

17.

El Deeb H, Khodeer S . Blastocystis spp.: frequency and subtype distribution in iron deficiency anemic versus non-anemic subjects from Egypt. J Parasitol. 2013; 99(4):599-602. DOI: 10.1645/12-80.1. View

18.

Bahrami F, Babaei E, Badirzadeh A, Riabi T, Abdoli A . Blastocystis, urticaria, and skin disorders: review of the current evidences. Eur J Clin Microbiol Infect Dis. 2019; 39(6):1027-1042. DOI: 10.1007/s10096-019-03793-8. View

19.

Muller I, Yap P, Steinmann P, Damons B, Schindler C, Seelig H . Intestinal parasites, growth and physical fitness of schoolchildren in poor neighbourhoods of Port Elizabeth, South Africa: a cross-sectional survey. Parasit Vectors. 2016; 9(1):488. PMC: 5011914. DOI: 10.1186/s13071-016-1761-5. View

20.

Stenzel D, Boreham P . Blastocystis hominis revisited. Clin Microbiol Rev. 1996; 9(4):563-84. PMC: 172910. DOI: 10.1128/CMR.9.4.563. View