Immune Infiltration Analysis Based on Pyroptosis-related Gene in Metabolic Dysfunction-associated Fatty Liver Disease

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Aug 15

PMID 39145004

Authors

Xin Lian

Xulei Tang

Affiliations

Soon will be listed here.

Abstract

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic disease that can involve pyroptosis. The primary objective of this study was to conduct a thorough and comprehensive analysis the pyroptosis-related genes in MAFLD.

Methods: We identified pyroptosis-related differentially expressed genes (PRDEGs) in both healthy individuals and MAFLD patients. Using various bioinformatic approaches, we conducted an immune infiltration analysis from multiple perspectives.

Results: A total of 20 pyroptosis-related LASSO genes were obtained, and 10 hub genes were used to do immune infiltration analysis. The hub genes were utilized in the construction of interaction networks between mRNA-miRNA and mRNA-TF. Immune characteristics analysis revealed multiple immune cell types significantly related to PRDEG expression, particularly genes HSP90AA1, TSLP, CDK9, and BRD4.

Conclusion: Pyroptosis-related immune infiltration might be a mechanism of MAFLD progression and offers a research direction for potential treatment techniques.

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