Sleep in Psychotic Disorders: Results From Nationwide SUPER Finland Study

Overview

Journal Schizophr Bull Open

Date 2024 Aug 15

PMID 39144769

Authors

Erik Cederlof

Minna Holm

Markku Lahteenvuo

Willehard Haaki

Jarmo Hietala

Katja Hakkinen

Erkki Isometsa

Tuomas Jukuri

Risto Kajanne

Olli Kampman

Tuula Kieseppa

Kaisla Lahdensuo

Jouko Lonnqvist

Teemu Mannynsalo

Jussi Niemi-Pynttari

Kimmo Suokas

Jaana Suvisaari

Jari Tiihonen

Hannu Turunen

Asko Wegelius

Juha Veijola

Aarno Palotie

Tiina Paunio

Affiliations

Soon will be listed here.

Abstract

Objective: Characterizing sleep in patients with schizophrenia, schizoaffective disorder, bipolar disorder, and psychotic depression.

Methods: This cross-sectional questionnaire study is based on the SUPER study sample, which is part of the Stanley Global Neuropsychiatric Genomics Initiative. The study is a multicentre, nationwide Finnish study consisting of patients ( = 8 623) both in primary and specialized health care. The main measurements were sleep duration, difficulties initiating sleep, early morning awakenings, and fatigue. These results were compared with a nationally representative sample of the Finnish population from the Health 2000 survey ( = 7 167) with frequency and logistic regression analyses.

Results: Patients had more sleep problems compared with the general population, especially young and middle-aged patients (Difficulties initiating sleep in young patients odds ratio = 12.3, 95% CI 9.8-15.4). Long sleep duration was the most deviating property of the sleep characteristics, being particularly common among young patients with schizophrenia (odds ratio = 27.9, 95% CI 22.1-35.2, 47.4% vs 3.3% prevalence). All sleep problems were associated with worse subjective health. We also conducted a latent class analysis, resulting in a cluster relatively free of sleep problems (58% of patients), an insomnia symptom cluster (26%), and a hypersomnia symptom cluster (15%).

Conclusions: In our sample, patients with psychotic disorders have more sleep problems-especially long sleep duration but also insomnia symptoms-compared with the general population. The patients can in a latent class analysis of their sleep symptoms be divided into groups with differing sleep profiles.

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