Cytoplasmic Nucleoporin Assemblage: the Cellular Artwork in Physiology and Disease

Overview

Journal Nucleus

Date 2024 Aug 13

PMID 39135336

Authors

Junyan Lin

Izabela Sumara

Affiliations

Soon will be listed here.

Abstract

Nucleoporins, essential proteins building the nuclear pore, are pivotal for ensuring nucleocytoplasmic transport. While traditionally confined to the nuclear envelope, emerging evidence indicates their presence in various cytoplasmic structures, suggesting potential non-transport-related roles. This review consolidates findings on cytoplasmic nucleoporin assemblies across different states, including normal physiological conditions, stress, and pathology, exploring their structural organization, formation dynamics, and functional implications. We summarize the current knowledge and the latest concepts on the regulation of nucleoporin homeostasis, aiming to enhance our understanding of their unexpected roles in physiological and pathological processes.

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