An Investigation into the Phytochemical Content and Antioxidant, Antidiabetic, and Wound-Healing Activities of Found in Brunei Darussalam

Overview

Journal ScientificWorldJournal

Publisher Wiley

Specialty Biology

Date 2024 Aug 12

PMID 39130077

Authors

Amanina Yusrina Taufik

Hartini Mohd Yasin

Norhayati Ahmad

Masayoshi Arai

Fairuzeta Jaafar

Affiliations

Soon will be listed here.

Abstract

This present study aimed to investigate the phytochemical content and antioxidant and antidiabetic activities of leaves (CL) and roots (CR) found in Brunei Darussalam. Phytochemical screening showed that CL and CR extracts contain saponins, tannins, glycosides, and terpenoids. CR showed higher total phenolic content (TPC), but lower total flavonoid content (TFC) when compared to CL. The high TPC in CR contributed to its potent radical scavenging activity (RSA) against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and strong ferric reducing antioxidant power (FRAP). Additionally, CR exerted significant inhibition of ∝-glucosidase and ∝-amylase, suggesting a potential link between the chemical compounds and its antioxidant and antidiabetic effects. In the animal study of antihyperglycemic activity, treatment with 250 mg/kg body weight (b.w.) of the CL extract normalised the blood glucose levels and improved body weight gain of alloxan-induced diabetic rats within 14 weeks. Furthermore, our investigation into the wound-healing effects of young leaves (YCL) and matured leaves (MCL) showed a significant reduction in wound size on Day 3, 5, and 7 of the experimental study, indicating its wound-healing potential. Based on our findings, can be consumed as part of a balanced diet due to its antioxidant and antidiabetic properties.

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