Clinical Protocol Phase II Study of Tumor Infiltrating Lymphocytes in Advanced Tumors with Alterations in the SWI/SNF Complex: the TILTS Study

Overview

Journal Future Oncol

Specialty Oncology

Date 2024 Aug 12

PMID 39129675

Authors

Juan Martin-Liberal

Elena Garralda

Jesus Garcia-Donas

Juan Jose Soto-Castillo

Alberto Mussetti

Carles Codony

Silvia Martin-Lluesma

Susana Munoz

Vladimir Galvao

Julia Lostes

Marta Rotxes

Cristina Prat-Vidal

Jara Palomero

Ainhoa Munoz

Rafael Moreno

Xavier Garcia Del Muro

Anna Sureda

Ramon Alemany

Alena Gros

Josep Maria Piulats

Affiliations

Soon will be listed here.

Abstract

The SWI/SNF complex is a chromatin remodeling complex comprised by several proteins such as SMARCA4 or SMARCB1. Mutations in its components can lead to the development of aggressive rhabdoid tumors such as epithelioid sarcoma, malignant rhabdoid tumor or small cell carcinoma of the ovary hypercalcemic type, among others. These malignancies tend to affect young patients and their prognosis is poor given the lack of effective treatments. Characteristically, these tumors are highly infiltrated by TILs, suggesting that some lymphocytes are recognizing tumor antigens. The use of those TILs as a therapeutic strategy is a promising approach worth exploring. Here, we report the clinical protocol of the TILTS study, a Phase II clinical trial assessing personalized adoptive cell therapy with TILs in patients affected by these tumor types.: 2023-504632-17-00 (www.clinicaltrialsregister.eu) (ClinicalTrials.gov).

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