Development and Validation of the Oral Lichen Planus-Disease Activity Scale: a Novel Tool for Comprehensive Clinical Assessment

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2024 Aug 11

PMID 39129032

Authors

Preeyaporn Somsak

Pornpan Piboonratanakit

Surawut Pongsiriwet

Kraisorn Sappayatosok

Wilairat Sarideechaigul

Patrayu Taebunpakul

Kununya Pimolbutr

Chalatip Chompunud Na Ayudhya

Nawaporn Pengpis

Paswach Wiriyakijja

Affiliations

Soon will be listed here.

Abstract

Objective: To develop and validate the Oral Lichen Planus-Disease Activity Scale (OLP-DAS) for assessing overall disease activity of OLP.

Methods: The OLP-DAS was created by refining the Thongprasom criteria, incorporating inputs from the literature and expert review, and integrating pain assessment. Content validity was evaluated in a virtual meeting with 8 Oral Medicine specialists. Reliability and validity of the final version were examined. Seventeen OLP subjects were assessed for disease activity by 10 investigators using the OLP-DAS, Oral Disease Severity Score (ODSS), OLP-Investigator Global Assessment (OLP-IGA), and Reticular-Erythema-Ulcerative (REU) scale. Convergent validity was assessed by rating 160 OLP subjects using the OLP-DAS, ODSS, and OLP-IGA. Inter-rater and intra-rater reliability, along with convergent validity, were analyzed using intraclass correlation coefficients (ICCs) and Spearman's rank correlation coefficients (r).

Results: The final OLP-DAS achieved excellent content validity indices. Inter-rater and intra-rater ICCs for total OLP-DAS scores were 0.93 and 0.96, respectively. Total OLP-DAS scores exhibited strong positive correlations with the ODSS and OLP-IGA (r = 0.94 and r = 0.76; P < 0.001, respectively). The OLP Severity Index (OLP-SI), a component of the OLP-DAS, showed very strong positive correlations with OLP disease activity parameters of the ODSS (r = 0.90; P < 0.001).

Conclusions: The OLP-DAS is a valid and reliable clinician-reported outcome measure (CROM) for evaluating OLP disease activity.

Clinical Relevance: The OLP-DAS, as a standardized CROM for OLP, is valuable for both routine clinical assessments and research applications.

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