Effect of Bacteriocins on the Intestinal Microbiota

Overview

Journal Eurasian J Med

Publisher Aves

Specialty General Medicine

Date 2024 Aug 11

PMID 39128034

Authors

Selin Dogan

Taha Yasin Koc

Mehmet Karadayi

Affiliations

Soon will be listed here.

Abstract

Intestinal microbiota, which plays an important role in human health by interacting with each other or with its hosts, is afected by many endogenous and exogenous factors. Any change in the composition and functionality of the intestinal microbiota, both in number and diversity, causes disruption of intestinal functioning and paves the way for many diseases. In this regard, many antimicrobial peptides, especially bacteriocins, synthesized by lactic acid bacteria are thought to be natural resources with a high potential for the protection of the intestinal microbiota and the treatment of intestinal diseases. Both the intestinal microbiota itself and many foodborne bacteria produce bacteriocins that can inhibit pathogenic microorganisms that cause serious health problems and regulate the intestinal microbiota. This review aims to provide a comprehensive overview of the intestinal microbiota, the properties of lactic acid bacteria, their bacteriocins, and the efects of bacteriocins on the human health.

Citing Articles

Current status and potential of bacteriocin-producing lactic acid bacteria applied in the food industry.

Liang Q, Zhou W, Peng S, Liang Z, Liu Z, Zhu C Curr Res Food Sci. 2025; 10:100997.

PMID: 39995467 PMC: 11849202. DOI: 10.1016/j.crfs.2025.100997.

References

Stedman A, Brunner K, Nigro G . Decrypting the communication between microbes and the intestinal mucosa-A brief review on Pathogénie Microbienne Moléculaire's latest research. Cell Microbiol. 2019; 21(11):e13118. DOI: 10.1111/cmi.13118. View

Teng Y, Yang X, Li G, Zhu Y, Zhang Z . Habitats Show More Impacts Than Host Species in Shaping Gut Microbiota of Sympatric Rodent Species in a Fragmented Forest. Front Microbiol. 2022; 13:811990. PMC: 8859092. DOI: 10.3389/fmicb.2022.811990. View

Sallan S, Yilmaz Oral Z, Kaya M . A Review on the Role of Lactic Acid Bacteria in the Formation and Reduction of Volatile Nitrosamines in Fermented Sausages. Foods. 2023; 12(4). PMC: 9955677. DOI: 10.3390/foods12040702. View

Scott K, Gratz S, Sheridan P, Flint H, Duncan S . The influence of diet on the gut microbiota. Pharmacol Res. 2012; 69(1):52-60. DOI: 10.1016/j.phrs.2012.10.020. View

Cui Y, Zhang C, Wang Y, Shi J, Zhang L, Ding Z . Class IIa bacteriocins: diversity and new developments. Int J Mol Sci. 2012; 13(12):16668-707. PMC: 3546714. DOI: 10.3390/ijms131216668. View

Baquero F, Lanza V, Baquero M, Del Campo R, Bravo-Vazquez D . Microcins in : Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere. Front Microbiol. 2019; 10:2261. PMC: 6795089. DOI: 10.3389/fmicb.2019.02261. View

Bauerl C, Umu O, Hernandez P, Diep D, Perez-Martinez G . A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice. J Vis Exp. 2017; (125). PMC: 5612588. DOI: 10.3791/56053. View

Yilmaz E, Gul M . Effects of cumin (Cuminum cyminum L.) essential oil and chronic heat stress on growth performance, carcass characteristics, serum biochemistry, antioxidant enzyme activity, and intestinal microbiology in broiler chickens. Vet Res Commun. 2022; 47(2):861-875. DOI: 10.1007/s11259-022-10048-z. View

Klu Y, Chen J . Influence of probiotics, included in peanut butter, on the fate of selected Salmonella and Listeria strains under simulated gastrointestinal conditions. J Appl Microbiol. 2016; 120(4):1052-60. DOI: 10.1111/jam.13084. View

10.

van Staden D, Brand A, Endo A, Dicks L . Nisin F, intraperitoneally injected, may have a stabilizing effect on the bacterial population in the gastro-intestinal tract, as determined in a preliminary study with mice as model. Lett Appl Microbiol. 2011; 53(2):198-201. DOI: 10.1111/j.1472-765X.2011.03091.x. View

11.

Aslam H, Green J, Jacka F, Collier F, Berk M, Pasco J . Fermented foods, the gut and mental health: a mechanistic overview with implications for depression and anxiety. Nutr Neurosci. 2018; 23(9):659-671. DOI: 10.1080/1028415X.2018.1544332. View

12.

OHara A, Shanahan F . The gut flora as a forgotten organ. EMBO Rep. 2006; 7(7):688-93. PMC: 1500832. DOI: 10.1038/sj.embor.7400731. View

13.

Kim S, Covington A, Pamer E . The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens. Immunol Rev. 2017; 279(1):90-105. PMC: 6026851. DOI: 10.1111/imr.12563. View

14.

Heilbronner S, Krismer B, Brotz-Oesterhelt H, Peschel A . The microbiome-shaping roles of bacteriocins. Nat Rev Microbiol. 2021; 19(11):726-739. DOI: 10.1038/s41579-021-00569-w. View

15.

Fernandes A, Jobby R . Bacteriocins from lactic acid bacteria and their potential clinical applications. Appl Biochem Biotechnol. 2022; 194(10):4377-4399. DOI: 10.1007/s12010-022-03870-3. View

16.

Dobson A, Cotter P, Ross R, Hill C . Bacteriocin production: a probiotic trait?. Appl Environ Microbiol. 2011; 78(1):1-6. PMC: 3255625. DOI: 10.1128/AEM.05576-11. View

17.

Ghaisas S, Maher J, Kanthasamy A . Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacol Ther. 2015; 158:52-62. PMC: 4747781. DOI: 10.1016/j.pharmthera.2015.11.012. View

18.

Cleveland J, Montville T, Nes I, Chikindas M . Bacteriocins: safe, natural antimicrobials for food preservation. Int J Food Microbiol. 2002; 71(1):1-20. DOI: 10.1016/s0168-1605(01)00560-8. View

19.

Caggianiello G, Kleerebezem M, Spano G . Exopolysaccharides produced by lactic acid bacteria: from health-promoting benefits to stress tolerance mechanisms. Appl Microbiol Biotechnol. 2016; 100(9):3877-86. DOI: 10.1007/s00253-016-7471-2. View

20.

Pessione E . Lactic acid bacteria contribution to gut microbiota complexity: lights and shadows. Front Cell Infect Microbiol. 2012; 2:86. PMC: 3417654. DOI: 10.3389/fcimb.2012.00086. View