Genetic Features of Tongue Cancer Recurrence in Young Adults

Overview

Journal Bull Exp Biol Med

Publisher Springer

Specialty General Medicine

Date 2024 Aug 11

PMID 39127975

Authors

E S Kolegova

A A Schegoleva

R S Vorobev

I K Fedorova

D E Kulbakin

A P Polyakov

A V Mordovsky

L P Yakovleva

A S Vyalov

V T Tsiklauri

M A Kropotov

N G Suchkova

N S Sukortseva

I V Reshetov

E L Choinzonov

E V Denisov

Affiliations

Soon will be listed here.

Abstract

To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor. In addition, the primary tumor and recurrence tongue cancer tissue harbored amplification of the 20p13 region containing C20orf96, DEFB125, DEFB126, DEFB127, DEFB128, DEFB129, DEFB132, and ZCCHC3 genes. Thus, genetic alterations have been identified that are associated with tongue cancer recurrence in young adults.

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