Extra Virgin Olive Oil and Metabolic Diseases

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Aug 10

PMID 39125686

Authors

Vasilis Tsimihodimos

Ourania Psoma

Affiliations

Soon will be listed here.

Abstract

Over the last few decades, metabolic syndrome coexisting with cardiovascular disease has evolved into a pandemic, making the need for more food-oriented therapeutic approaches and a redefinition of lifestyle imperative, with the Mediterranean diet being the linchpin of this effort. Extra virgin olive oil (EVOO), the key pillar of the Mediterranean diet and one of the most notorious edible oils worldwide, owes its popularity not only to its characteristic aromas and taste but mainly to a series of beneficial health attributes including anti-diabetic, hypolipidemic, anti-hypertensive and anti-obesity actions. In this narrative review, we aimed to illustrate and enlighten EVOO's metabolic properties through a pathogenetic approach, investigating its potential role in metabolic and cardiovascular health.

Citing Articles

Improving the Biostability of Extra Virgin Olive Oil with Olive Fruit Extract During Prolonged Deep Frying.

Mehany T, Gonzalez-Saiz J, Pizarro C Foods. 2025; 14(2).

PMID: 39856925 PMC: 11765049. DOI: 10.3390/foods14020260.

References

Romaguera D, Norat T, Vergnaud A, Mouw T, May A, Agudo A . Mediterranean dietary patterns and prospective weight change in participants of the EPIC-PANACEA project. Am J Clin Nutr. 2010; 92(4):912-21. DOI: 10.3945/ajcn.2010.29482. View

Qian F, Korat A, Malik V, Hu F . Metabolic Effects of Monounsaturated Fatty Acid-Enriched Diets Compared With Carbohydrate or Polyunsaturated Fatty Acid-Enriched Diets in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diabetes Care. 2016; 39(8):1448-57. PMC: 4955926. DOI: 10.2337/dc16-0513. View

Fito M, Cladellas M, de la Torre R, Marti J, Munoz D, Schroder H . Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial. Eur J Clin Nutr. 2007; 62(4):570-4. DOI: 10.1038/sj.ejcn.1602724. View

Castejon M, Montoya T, Ortega-Vidal J, Altarejos J, Alarcon-de-la-Lastra C . Ligstroside aglycon, an extra virgin olive oil secoiridoid, prevents inflammation by regulation of MAPKs, JAK/STAT, NF-κB, Nrf2/HO-1, and NLRP3 inflammasome signaling pathways in LPS-stimulated murine peritoneal macrophages. Food Funct. 2022; 13(19):10200-10209. DOI: 10.1039/d2fo00351a. View

Castaner O, Covas M, Khymenets O, Nyyssonen K, Konstantinidou V, Zunft H . Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans. Am J Clin Nutr. 2012; 95(5):1238-44. DOI: 10.3945/ajcn.111.029207. View

Bartimoccia S, Cammisotto V, Nocella C, Ben M, DAmico A, Castellani V . Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients. Nutrients. 2022; 14(10). PMC: 9145083. DOI: 10.3390/nu14102153. View

Luisi M, Lucarini L, Biffi B, Rafanelli E, Pietramellara G, Durante M . Effect of Mediterranean Diet Enriched in High Quality Extra Virgin Olive Oil on Oxidative Stress, Inflammation and Gut Microbiota in Obese and Normal Weight Adult Subjects. Front Pharmacol. 2019; 10:1366. PMC: 6872540. DOI: 10.3389/fphar.2019.01366. View

Perez-Martinez P, Garcia-Quintana J, Yubero-Serrano E, Tasset-Cuevas I, Tunez I, Garcia-Rios A . Postprandial oxidative stress is modified by dietary fat: evidence from a human intervention study. Clin Sci (Lond). 2010; 119(6):251-61. DOI: 10.1042/CS20100015. View

Romani A, Ieri F, Urciuoli S, Noce A, Marrone G, Nediani C . Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of L. Nutrients. 2019; 11(8). PMC: 6724211. DOI: 10.3390/nu11081776. View

10.

Anderson-Vasquez H, Perez-Martinez P, Ortega Fernandez P, Wanden-Berghe C . Impact of the consumption of a rich diet in butter and it replacement for a rich diet in extra virgin olive oil on anthropometric, metabolic and lipid profile in postmenopausal women. Nutr Hosp. 2015; 31(6):2561-70. DOI: 10.3305/nh.2015.31.6.8732. View

11.

Violi F, Loffredo L, Pignatelli P, Angelico F, Bartimoccia S, Nocella C . Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects. Nutr Diabetes. 2015; 5:e172. PMC: 4521177. DOI: 10.1038/nutd.2015.23. View

12.

Melero V, Arnoriaga M, Barabash A, Valerio J, Valle L, OConnor R . An Early Mediterranean-Based Nutritional Intervention during Pregnancy Reduces Metabolic Syndrome and Glucose Dysregulation Rates at 3 Years Postpartum. Nutrients. 2023; 15(14). PMC: 10383706. DOI: 10.3390/nu15143252. View

13.

Loizzo M, Said A, Tundis R, Rashed K, Statti G, Hufner A . Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae). Phytother Res. 2006; 21(1):32-6. DOI: 10.1002/ptr.2008. View

14.

Bozzetto L, Alderisio A, Giorgini M, Barone F, Giacco A, Riccardi G . Extra-Virgin Olive Oil Reduces Glycemic Response to a High-Glycemic Index Meal in Patients With Type 1 Diabetes: A Randomized Controlled Trial. Diabetes Care. 2016; 39(4):518-24. DOI: 10.2337/dc15-2189. View

15.

Giuliani A, Cerretani L, Cichelli A . Chlorophylls in olive and in olive oil: chemistry and occurrences. Crit Rev Food Sci Nutr. 2011; 51(7):678-90. DOI: 10.1080/10408391003768199. View

16.

Storniolo C, Rosello-Catafau J, Pinto X, Mitjavila M, Moreno J . Polyphenol fraction of extra virgin olive oil protects against endothelial dysfunction induced by high glucose and free fatty acids through modulation of nitric oxide and endothelin-1. Redox Biol. 2014; 2:971-7. PMC: 4215463. DOI: 10.1016/j.redox.2014.07.001. View

17.

Lammi C, Bellumori M, Cecchi L, Bartolomei M, Bollati C, Clodoveo M . Extra Virgin Olive Oil Phenol Extracts Exert Hypocholesterolemic Effects through the Modulation of the LDLR Pathway: In Vitro and Cellular Mechanism of Action Elucidation. Nutrients. 2020; 12(6). PMC: 7352813. DOI: 10.3390/nu12061723. View

18.

Razquin C, Martinez J, Martinez-Gonzalez M, Mitjavila M, Estruch R, Marti A . A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain. Eur J Clin Nutr. 2009; 63(12):1387-93. DOI: 10.1038/ejcn.2009.106. View

19.

Davis C, Bryan J, Hodgson J, Murphy K . Definition of the Mediterranean Diet; a Literature Review. Nutrients. 2015; 7(11):9139-53. PMC: 4663587. DOI: 10.3390/nu7115459. View

20.

Zhao Z, Shi A, Wang Q, Zhou J . High Oleic Acid Peanut Oil and Extra Virgin Olive Oil Supplementation Attenuate Metabolic Syndrome in Rats by Modulating the Gut Microbiota. Nutrients. 2019; 11(12). PMC: 6950752. DOI: 10.3390/nu11123005. View