Identification of Biomarkers Associated with Tolerance

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Aug 10

PMID 39124986

Authors

Puseletso O J Tswaai

Wilma A Augustyn

Thierry Regnier

Wilma du Plooy

Affiliations

Soon will be listed here.

Abstract

Citrus black spot (CBS) is a fungal disease caused by Kiely, (McAlpine Van der Aa), with most cultivars being susceptible to infection. Currently, disease control is based on the application of protective fungicides, which is restricted due to resistance, health and environmental concerns. Although using natural products for disease management is gaining momentum, more advances are required. This study obtained the metabolic profiles of the essential oil and cuticular waxes of two citrus cultivars with a varying susceptibility to CBS infection using gas chromatography-mass spectrometry. A multivariate data analysis identified possible biomarker compounds that contributed to the difference in susceptibility between the two cultivars. Several identified biomarkers were tested in vitro for their antifungal properties against . Two biomarkers, propanoic acid and linalool, were able to completely inhibit pathogen growth at 750 mg/L and 2000 mg/L, respectively.

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