Photocatalytic Generation of Singlet Oxygen by Graphitic Carbon Nitride for Antibacterial Applications

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2024 Aug 10

PMID 39124449

Authors

Davida Briana DuBois

Isabelle Rivera

Qiming Liu

Bingzhe Yu

Kevin Singewald

Glenn L Millhauser

Chad Saltikov

Shaowei Chen

Affiliations

Soon will be listed here.

Abstract

Carbon-based functional nanocomposites have emerged as potent antimicrobial agents and can be exploited as a viable option to overcome antibiotic resistance of bacterial strains. In the present study, graphitic carbon nitride nanosheets are prepared by controlled calcination of urea. Spectroscopic measurements show that the nanosheets consist of abundant carbonyl groups and exhibit apparent photocatalytic activity under UV photoirradiation towards the selective production of singlet oxygen. Therefore, the nanosheets can effectively damage the bacterial cell membranes and inhibit the growth of bacterial cells, such as Gram-negative , as confirmed in photodynamic, fluorescence microscopy, and scanning electron microscopy measurements. The results from this research highlight the unique potential of carbon nitride derivatives as potent antimicrobial agents.

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