Adverse In-Hospital Outcomes After Radical Prostatectomy in Leukemia History Patients

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2024 Aug 10

PMID 39123490

Authors

Fabian Falkenbach

Francesco Di Bello

Natali Rodriguez Penaranda

Mattia Longoni

Andrea Marmiroli

Quynh Chi Le

Zhe Tian

Jordan A Goyal

Nicola Longo

Salvatore Micali

Alberto Briganti

Ottavio de Cobelli

Felix K H Chun

Fred Saad

Shahrokh F Shariat

Lars Budaus

Markus Graefen

Pierre I Karakiewicz

Affiliations

Soon will be listed here.

Abstract

Introduction: Leukemia history affects some radical prostatectomy (RP) patients. Although its prevalence and effect as an adverse risk factor are well known in cardiac surgery, the number of RP patients with a leukemia history, as well as their rate of adverse in-hospital outcomes, are unknown.

Methods: We identified RP patients (National Inpatient Sample 2000-2019), stratified according to the presence or absence of a leukemia history. Descriptive analyses, propensity score matching (PSM, ratio 1:10), and multivariable logistic regression models were used.

Results: Of 259,939 RP patients, 416 (0.2%) had a leukemia history. Their proportion increased from 0.1 to 0.2% covering the study span ( < 0.01). Leukemia history patients were older (median age, 64 vs. 62 years, < 0.001). After PSM for age, insurance status, ethnicity, pelvic lymph node dissection, and Charlson Comorbidity Index, leukemia history RP patients exhibited higher rates of acute kidney injury (<2.6 vs. 0.9%; Odds Ratio [OR] 2.0, = 0.02), more frequently underwent dialysis (3.6 vs. 1.9%; OR 1.9, = 0.03), and more frequently had a length of stay exceeding one week (4.8 vs. 2.5%; OR 2.0, = 0.006).

Conclusions: Although leukemia history RP patients are rare, their numbers have increased. Renal complications and extended hospital stays are more frequent in those individuals.

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References

He H, Cheng L, Weiss L, Chu P . Clinical outcome of incidental pelvic node malignant B-cell lymphomas discovered at the time of radical prostatectomy. Leuk Lymphoma. 2007; 48(10):1976-80. DOI: 10.1080/10428190701584007. View

Terris M, Hausdorff J, Freiha F . Hematolymphoid malignancies diagnosed at the time of radical prostatectomy. J Urol. 1997; 158(4):1457-9. View

Weir E, Epstein J . Incidental small lymphocytic lymphoma/chronic lymphocytic leukemia in pelvic lymph nodes excised at radical prostatectomy. Arch Pathol Lab Med. 2003; 127(5):567-72. DOI: 10.5858/2003-127-0567-ISLCLL. View

Deyo R, Cherkin D, Ciol M . Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992; 45(6):613-9. DOI: 10.1016/0895-4356(92)90133-8. View

Fecher A, Birdas T, Haybron D, Papasavas P, Evers D, Caushaj P . Cardiac operations in patients with hematologic malignancies. Eur J Cardiothorac Surg. 2004; 25(4):537-40. DOI: 10.1016/j.ejcts.2003.12.006. View

Nguyen A, Schaff H, Arghami A, Bagameri G, Cicek M, Crestanello J . Impact of Hematologic Malignancies on Outcome of Cardiac Surgery. Ann Thorac Surg. 2020; 111(4):1278-1283. DOI: 10.1016/j.athoracsur.2020.06.033. View

Winstanley A, Sandison A, Bott S, Dogan A, Parkinson M . Incidental findings in pelvic lymph nodes at radical prostatectomy. J Clin Pathol. 2002; 55(8):623-6. PMC: 1769730. DOI: 10.1136/jcp.55.8.623. View

Pata G, Damiani E, Tognali D, Solaini L, Watt J, Ragni F . Outcomes of open splenectomy for hematologic malignancy with splenomegaly: a contemporary perspective. Am Surg. 2015; 81(4):414-20. View

Hanna N, Sun M, Trinh Q, Hansen J, Bianchi M, Montorsi F . Propensity-score-matched comparison of perioperative outcomes between open and laparoscopic nephroureterectomy: a national series. Eur Urol. 2012; 61(4):715-21. DOI: 10.1016/j.eururo.2011.12.026. View

10.

Eisenberger C, Walsh P, Eisenberger M, Chow N, Partin A, Mostwin J . Incidental non-Hodgkin's lymphoma in patients with localized prostate cancer. Urology. 1999; 53(1):175-9. DOI: 10.1016/s0090-4295(98)00422-1. View

11.

Ma H, Wang S, OBrien S, Kern M, Gupta P . How we approach the perioperative management of patients with chronic lymphocytic leukaemia receiving continuous cancer-directed therapies. Br J Haematol. 2023; 201(2):215-221. DOI: 10.1111/bjh.18661. View

12.

Newman J, Wagner T, Naziri Q, North W, Navale S, Klika A . Hematologic Malignancies Are Associated with Adverse Perioperative Outcomes following Total Knee Arthroplasty. J Knee Surg. 2017; 31(4):291-301. DOI: 10.1055/s-0037-1603335. View

13.

Tlili G, Ammar H, Majdoub W, Dziri S, Farhat W, Acacha E . Incidental chronic lymphocytic leukemia diagnosed following radical prostatectomy for prostate cancer: A case report. Ann Med Surg (Lond). 2021; 68:102516. PMC: 8274301. DOI: 10.1016/j.amsu.2021.102516. View

14.

Baeker Bispo J, Pinheiro P, Kobetz E . Epidemiology and Etiology of Leukemia and Lymphoma. Cold Spring Harb Perspect Med. 2019; 10(6). PMC: 7263093. DOI: 10.1101/cshperspect.a034819. View

15.

Mazzone E, Mistretta F, Knipper S, Tian Z, Palumbo C, Gandaglia G . Temporal trends and social barriers for inpatient palliative care delivery in metastatic prostate cancer patients receiving critical care therapies. Prostate Cancer Prostatic Dis. 2019; 23(2):260-268. DOI: 10.1038/s41391-019-0183-9. View

16.

Sommer S, Lange V, Yildirim C, Schimmer C, Aleksic I, Wagner C . Cardiac surgery and hematologic malignancies: a retrospective single-center analysis of 56 consecutive patients. Eur J Cardiothorac Surg. 2010; 40(1):173-8. DOI: 10.1016/j.ejcts.2010.10.031. View

17.

Madrigal J, Tran Z, Hadaya J, Sanaiha Y, Benharash P . Impact of Chronic Lymphocytic Leukemia on Outcomes and Readmissions After Cardiac Operations. Ann Thorac Surg. 2021; 114(1):152-159. DOI: 10.1016/j.athoracsur.2021.07.059. View

18.

Chu P, Huang Q, Weiss L . Incidental and concurrent malignant lymphomas discovered at the time of prostatectomy and prostate biopsy: a study of 29 cases. Am J Surg Pathol. 2005; 29(5):693-9. DOI: 10.1097/01.pas.0000153122.65138.b1. View

19.

Quan H, Sundararajan V, Halfon P, Fong A, Burnand B, Luthi J . Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care. 2005; 43(11):1130-9. DOI: 10.1097/01.mlr.0000182534.19832.83. View

20.

Hirotsu K, Loh T, Cheng J, Jiang S . Postoperative Complications in Chronic Lymphocytic Leukemia Patients Undergoing Mohs Surgery: Increased Risk of Bleeding-Related Complications From Ibrutinib. Dermatol Surg. 2022; 49(1):103-105. DOI: 10.1097/DSS.0000000000003649. View