Hallmarks of Perineural Invasion in Pancreatic Ductal Adenocarcinoma: New Biological Dimensions

Overview

Journal Front Oncol

Specialty Oncology

Date 2024 Aug 9

PMID 39119085

Authors

Yaquan Sun

Wei Jiang

Xiang Liao

Dongqing Wang

Affiliations

Soon will be listed here.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a high incidence rate and is directly associated with a poor prognosis. It involves close interaction among PDAC cells, nerves and the tumor microenvironment. In this review, we detailed discuss PNI-related pain, six specific steps of PNI, and treatment of PDAC with PNI and emphasize the importance of novel technologies for further investigation.

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