Mesoporous Zinc-polyphenol Nanozyme for Attenuating Renal Ischemia-reperfusion Injury

Overview

Journal Nanomedicine (Lond)

Specialty Biotechnology

Date 2024 Aug 8

PMID 39115910

Authors

Zepeng Li

Jingyue Qin

Youyou Feng

Chenguang Ding

Yingcong Guo

Zhenting Zhao

Shirui Sun

Jin Zheng

Mingzhen Zhang

Jing Zhang

Yilei Zhang

Jing Wei

Wujun Xue

Affiliations

Soon will be listed here.

Abstract

To target the reactive oxygen species (ROS) accumulation and renal tubular epithelial cell (rTEC) death in renal ischemia-reperfusion injury (IRI), we constructed a nanoparticle that offers ROS scavenging and rTEC-death inhibition: mesoporous zinc-tannic acid nanozyme (ZnTA). After successfully constructing ZnTA, we proceeded to examine its effect on ROS accumulation, cellular ferroptosis and apoptosis, as well as injury severity. Malondialdehyde, Fe amounts and 4-HNE staining demonstrated that ZnTA effectively attenuated rTEC ferroptosis. TUNEL staining confirmed that Zn carried by ZnTA could effectively inhibit caspase 3 and caspase 9, mitigating apoptosis. Finally, it reduced renal IRI through the synergistic effect of ROS scavenging and cell-death inhibition. This study is expected to provide a paradigm for a combined therapeutic strategy for renal IRI.

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