Long-Term Effects of the Multicomponent Program BrainProtect on Cognitive Function: One-Year Follow-Up in Healthy Adults

Overview

Journal J Alzheimers Dis Rep

Publisher IOS Press

Date 2024 Aug 8

PMID 39114551

Authors

Michelle Celine Kunkler

Julia Maria Falkenreck

Anja Ophey

Katharina Dencker

Andrea Friese

Petra Jahr

Elke Kalbe

Gereon Nelles

M Cristina Polidori

Affiliations

Soon will be listed here.

Abstract

Background: Age-related neuronal changes impact cognitive integrity, which is a major contributor to health and quality of life. The best strategy to prevent cognitive decline and Alzheimer's disease is still debated.

Objective: To investigate the long-term effects of the eight-week multicomponent training program BrainProtect on cognitive abilities compared to general health counseling (GHC) in cognitively healthy adults in Germany.

Methods: Healthy adults (age ≥50 years) previously randomized to either GHC ( = 72) or BrainProtect (intervention group, IG, = 60) for eight-weeks (once weekly, 90 minutes, group-based) underwent a comprehensive neuropsychological test battery and health-related quality of life (HRQoL) evaluation 3- and 12-months after intervention end.

Results: Dropout rates were = 8 after 3 months and = 19 after 12 months. No significant long-term effect of BrainProtect was observed for the primary endpoint Consortium to Establish a Registry for Alzheimer's Disease (CERAD-Plus) total score. Logical reasoning was significantly improved ( = 0.024) 12 months after completion of the training program in IG participants compared to the GHC group independent of sex, age, education, diet, and physical activity. In IG participants, thinking flexibility ( = 0.019) and confrontational naming ( = 0.010) were improved 3 months after completing the intervention compared to the GHC group, however, after conservative Bonferroni adjustment, significance was lost.

Conclusions: BrainProtect independently improved logical reasoning compared to GHC up to 12 months after cognitive training's end in healthy adults. To uncover the long-term clinical significance of multicomponent cognitive training in healthy adults, studies with larger sample size and frequent follow up visits are necessary.

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