Cancer-associated Adipocytes in the Ovarian Cancer Microenvironment

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2024 Aug 8

PMID 39113876

Authors

Qiuling Cai

Jing Yang

Huiling Shen

Wenlin Xu

Affiliations

Soon will be listed here.

Abstract

The tumor microenvironment (TME) plays a critical role in high energy metabolism during tumorigenesis, progression and metastasis. Among them, adipocytes, as an important component of the TME, can transform into cancer-associated adipocytes (CAAs) through dedifferentiation via interactions with tumor cells. These CAAs provide nutrients, growth factors, cytokines and metabolites to the tumor and later transdifferentiate into other stromal cells at a later stage to alter tumor growth, metastasis and the drug response and ultimately influence the treatment and prognosis of ovarian cancer. This review outlines the physiological functions of CAAs and discusses the progress in the use of CAAs as therapeutic targets in ovarian cancer.

Citing Articles

Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants.

Long Y, Shi H, Ye J, Qi X Antioxidants (Basel). 2025; 14(1).

PMID: 39857448 PMC: 11762571. DOI: 10.3390/antiox14010114.

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