Regulated Anthocyanin Release Through Novel PH-responsive Peptide Hydrogels in Simulated Digestive Environment

Overview

Journal Food Chem X

Date 2024 Aug 8

PMID 39113736

Authors

Wenjun Li

Qianqian Bie

Kaihui Zhang

Fangzhou Linli

Wenyu Yang

Xianggui Chen

Pengfei Chen

Qi Qi

Affiliations

Soon will be listed here.

Abstract

The instability of anthocyanins significantly reduces their bioavailability as food nutrients. This proof-of-concept study aimed to develop efficient carriers for anthocyanins to overcome this challenge. Characterization of the hydrogels via SEM (scanning electron microscope) and rheological analysis revealed the formation of typical gel structures. MTT (methyl thiazolyl tetrazolium) and hemolysis assays confirmed that their high biocompatibility. Encapsulation efficiency analysis and fluorescence microscopy images demonstrated successful and efficient encapsulation of anthocyanins by pH-responsive hydrogels. Stability studies further validated the effect of peptide hydrogels in helping anthocyanin molecules withstand factors such as gastric acid, high temperatures, and heavy metals. Subsequently, responsive studies in simulated gastric (intestinal) fluid demonstrated that the pH-responsive peptide hydrogels could protect anthocyanin molecules from gastric acid while achieving rapid and complete release in intestinal fluid environments. These results indicate that these peptide hydrogels could stabilize anthocyanins and facilitate their controlled release, potentially leading to personalized delivery systems.

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